Migraine and cluster headache - the common link
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- Migraine and cluster headache – the common link
Final published version, 823 KB, PDF document
Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.
Original language | English |
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Article number | 89 |
Journal | Journal of Headache and Pain |
Volume | 19 |
Issue number | 1 |
Pages (from-to) | 1-15 |
ISSN | 1129-2369 |
DOIs | |
Publication status | Published - 2018 |
- Calcitonin Gene-Related Peptide/antagonists & inhibitors, Cluster Headache/blood, Deep Brain Stimulation/statistics & numerical data, Humans, Implantable Neurostimulators/statistics & numerical data, Migraine Disorders/blood, Nitroglycerin/adverse effects, Tryptamines/pharmacology
Research areas
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