Monocular visual deprivation suppresses excitability in adult human visual cortex
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Monocular visual deprivation suppresses excitability in adult human visual cortex. / Lou, Astrid Rosenstand; Madsen, Kristoffer Hougaard; Paulson, Olaf Bjarne; Julian, Hanne Olsen; Prause, Jan Ulrik; Siebner, Hartwig Roman; Kjaer, Troels Wesenberg.
In: Cerebral Cortex, Vol. 21, No. 12, 2011, p. 2876-82.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Monocular visual deprivation suppresses excitability in adult human visual cortex
AU - Lou, Astrid Rosenstand
AU - Madsen, Kristoffer Hougaard
AU - Paulson, Olaf Bjarne
AU - Julian, Hanne Olsen
AU - Prause, Jan Ulrik
AU - Siebner, Hartwig Roman
AU - Kjaer, Troels Wesenberg
PY - 2011
Y1 - 2011
N2 - The adult visual cortex maintains a substantial potential for plasticity in response to a change in visual input. For instance, transcranial magnetic stimulation (TMS) studies have shown that binocular deprivation (BD) increases the cortical excitability for inducing phosphenes with TMS. Here, we employed TMS to trace plastic changes in adult visual cortex before, during, and after 48 h of monocular deprivation (MD) of the right dominant eye. In healthy adult volunteers, MD-induced changes in visual cortex excitability were probed with paired-pulse TMS applied to the left and right occipital cortex. Stimulus-response curves were constructed by recording the intensity of the reported phosphenes evoked in the contralateral visual field at range of TMS intensities. Phosphene measurements revealed that MD produced a rapid and robust decrease in cortical excitability relative to a control condition without MD. The cortical excitability returned to preinterventional baseline levels within 3 h after the end of MD. The results show that in contrast to the excitability increase in response to BD, MD acutely triggers a reversible decrease in visual cortical excitability. This shows that the pattern of visual deprivation has a substantial impact on experience-dependent plasticity of the human visual cortex.
AB - The adult visual cortex maintains a substantial potential for plasticity in response to a change in visual input. For instance, transcranial magnetic stimulation (TMS) studies have shown that binocular deprivation (BD) increases the cortical excitability for inducing phosphenes with TMS. Here, we employed TMS to trace plastic changes in adult visual cortex before, during, and after 48 h of monocular deprivation (MD) of the right dominant eye. In healthy adult volunteers, MD-induced changes in visual cortex excitability were probed with paired-pulse TMS applied to the left and right occipital cortex. Stimulus-response curves were constructed by recording the intensity of the reported phosphenes evoked in the contralateral visual field at range of TMS intensities. Phosphene measurements revealed that MD produced a rapid and robust decrease in cortical excitability relative to a control condition without MD. The cortical excitability returned to preinterventional baseline levels within 3 h after the end of MD. The results show that in contrast to the excitability increase in response to BD, MD acutely triggers a reversible decrease in visual cortical excitability. This shows that the pattern of visual deprivation has a substantial impact on experience-dependent plasticity of the human visual cortex.
KW - Adult
KW - Female
KW - Humans
KW - Male
KW - Neuronal Plasticity
KW - Phosphenes
KW - Sensory Deprivation
KW - Transcranial Magnetic Stimulation
KW - Visual Cortex
KW - Young Adult
U2 - 10.1093/cercor/bhr082
DO - 10.1093/cercor/bhr082
M3 - Journal article
C2 - 21531780
VL - 21
SP - 2876
EP - 2882
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 12
ER -
ID: 40226803