Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis. / Ratzer, Rikke; Iversen, Pernille; Börnsen, Lars; Dyrby, Tim B; Christensen, Jeppe Romme; Ammitzbøll, Cecilie; Madsen, Camilla Gøbel; Garde, Ellen; Lyksborg, Mark; Andersen, Birgit; Hyldstrup, Lars; Sørensen, Per Soelberg; Siebner, Hartwig R; Sellebjerg, Finn.

In: Multiple Sclerosis Journal, Vol. 22, No. 7, 2016, p. 926–934.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ratzer, R, Iversen, P, Börnsen, L, Dyrby, TB, Christensen, JR, Ammitzbøll, C, Madsen, CG, Garde, E, Lyksborg, M, Andersen, B, Hyldstrup, L, Sørensen, PS, Siebner, HR & Sellebjerg, F 2016, 'Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis', Multiple Sclerosis Journal, vol. 22, no. 7, pp. 926–934. https://doi.org/10.1177/1352458515605908

APA

Ratzer, R., Iversen, P., Börnsen, L., Dyrby, T. B., Christensen, J. R., Ammitzbøll, C., Madsen, C. G., Garde, E., Lyksborg, M., Andersen, B., Hyldstrup, L., Sørensen, P. S., Siebner, H. R., & Sellebjerg, F. (2016). Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis. Multiple Sclerosis Journal, 22(7), 926–934. https://doi.org/10.1177/1352458515605908

Vancouver

Ratzer R, Iversen P, Börnsen L, Dyrby TB, Christensen JR, Ammitzbøll C et al. Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis. Multiple Sclerosis Journal. 2016;22(7):926–934. https://doi.org/10.1177/1352458515605908

Author

Ratzer, Rikke ; Iversen, Pernille ; Börnsen, Lars ; Dyrby, Tim B ; Christensen, Jeppe Romme ; Ammitzbøll, Cecilie ; Madsen, Camilla Gøbel ; Garde, Ellen ; Lyksborg, Mark ; Andersen, Birgit ; Hyldstrup, Lars ; Sørensen, Per Soelberg ; Siebner, Hartwig R ; Sellebjerg, Finn. / Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis. In: Multiple Sclerosis Journal. 2016 ; Vol. 22, No. 7. pp. 926–934.

Bibtex

@article{284701a7c12a49a0a4d0dcb3706fb75b,
title = "Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis",
abstract = "BACKGROUND: There is a large unmet need for treatments for patients with progressive multiple sclerosis (MS). Phase 2 studies with cerebrospinal fluid (CSF) biomarker outcomes may be well suited for the initial evaluation of efficacious treatments.OBJECTIVE: To evaluate the effect of monthly oral methylprednisolone pulse treatment on intrathecal inflammation in progressive MS.METHODS: In this open-label phase 2A study, 15 primary progressive and 15 secondary progressive MS patients received oral methylprednisolone pulse treatment for 60 weeks. Primary outcome was changes in CSF concentrations of osteopontin. Secondary outcomes were other CSF biomarkers of inflammation, axonal damage and demyelination; clinical scores; magnetic resonance imaging measures of disease activity, magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI); motor evoked potentials; and bone density scans.RESULTS: We found no change in the CSF concentration of osteopontin, but we observed significant improvement in clinical scores, MTR, DTI and some secondary CSF outcome measures. Adverse events were well-known side effects to methylprednisolone.CONCLUSION: Monthly methylprednisolone pulse treatment was safe, but had no effect on the primary outcome. However, improvements in secondary clinical and MRI outcome measures suggest that this treatment regimen may have a beneficial effect in progressive MS.",
author = "Rikke Ratzer and Pernille Iversen and Lars B{\"o}rnsen and Dyrby, {Tim B} and Christensen, {Jeppe Romme} and Cecilie Ammitzb{\o}ll and Madsen, {Camilla G{\o}bel} and Ellen Garde and Mark Lyksborg and Birgit Andersen and Lars Hyldstrup and S{\o}rensen, {Per Soelberg} and Siebner, {Hartwig R} and Finn Sellebjerg",
note = "{\textcopyright} The Author(s), 2015.",
year = "2016",
doi = "10.1177/1352458515605908",
language = "English",
volume = "22",
pages = "926–934",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications",
number = "7",

}

RIS

TY - JOUR

T1 - Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis

AU - Ratzer, Rikke

AU - Iversen, Pernille

AU - Börnsen, Lars

AU - Dyrby, Tim B

AU - Christensen, Jeppe Romme

AU - Ammitzbøll, Cecilie

AU - Madsen, Camilla Gøbel

AU - Garde, Ellen

AU - Lyksborg, Mark

AU - Andersen, Birgit

AU - Hyldstrup, Lars

AU - Sørensen, Per Soelberg

AU - Siebner, Hartwig R

AU - Sellebjerg, Finn

N1 - © The Author(s), 2015.

PY - 2016

Y1 - 2016

N2 - BACKGROUND: There is a large unmet need for treatments for patients with progressive multiple sclerosis (MS). Phase 2 studies with cerebrospinal fluid (CSF) biomarker outcomes may be well suited for the initial evaluation of efficacious treatments.OBJECTIVE: To evaluate the effect of monthly oral methylprednisolone pulse treatment on intrathecal inflammation in progressive MS.METHODS: In this open-label phase 2A study, 15 primary progressive and 15 secondary progressive MS patients received oral methylprednisolone pulse treatment for 60 weeks. Primary outcome was changes in CSF concentrations of osteopontin. Secondary outcomes were other CSF biomarkers of inflammation, axonal damage and demyelination; clinical scores; magnetic resonance imaging measures of disease activity, magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI); motor evoked potentials; and bone density scans.RESULTS: We found no change in the CSF concentration of osteopontin, but we observed significant improvement in clinical scores, MTR, DTI and some secondary CSF outcome measures. Adverse events were well-known side effects to methylprednisolone.CONCLUSION: Monthly methylprednisolone pulse treatment was safe, but had no effect on the primary outcome. However, improvements in secondary clinical and MRI outcome measures suggest that this treatment regimen may have a beneficial effect in progressive MS.

AB - BACKGROUND: There is a large unmet need for treatments for patients with progressive multiple sclerosis (MS). Phase 2 studies with cerebrospinal fluid (CSF) biomarker outcomes may be well suited for the initial evaluation of efficacious treatments.OBJECTIVE: To evaluate the effect of monthly oral methylprednisolone pulse treatment on intrathecal inflammation in progressive MS.METHODS: In this open-label phase 2A study, 15 primary progressive and 15 secondary progressive MS patients received oral methylprednisolone pulse treatment for 60 weeks. Primary outcome was changes in CSF concentrations of osteopontin. Secondary outcomes were other CSF biomarkers of inflammation, axonal damage and demyelination; clinical scores; magnetic resonance imaging measures of disease activity, magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI); motor evoked potentials; and bone density scans.RESULTS: We found no change in the CSF concentration of osteopontin, but we observed significant improvement in clinical scores, MTR, DTI and some secondary CSF outcome measures. Adverse events were well-known side effects to methylprednisolone.CONCLUSION: Monthly methylprednisolone pulse treatment was safe, but had no effect on the primary outcome. However, improvements in secondary clinical and MRI outcome measures suggest that this treatment regimen may have a beneficial effect in progressive MS.

U2 - 10.1177/1352458515605908

DO - 10.1177/1352458515605908

M3 - Journal article

C2 - 26432857

VL - 22

SP - 926

EP - 934

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 7

ER -

ID: 161848991