Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy

Research output: Contribution to journal › Journal article › Research › peer-review

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Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy. / Linnert, Mette; Iversen, Helle Klingenberg; Gehl, Julie.

In: Radiology and Oncology, Vol. 46, No. 4, 12.2012, p. 271-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Linnert, M, Iversen, HK & Gehl, J 2012, 'Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy', Radiology and Oncology, vol. 46, no. 4, pp. 271-8. https://doi.org/10.2478/v10019-012-0042-y

APA

Linnert, M., Iversen, H. K., & Gehl, J. (2012). Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy. Radiology and Oncology, 46(4), 271-8. https://doi.org/10.2478/v10019-012-0042-y

Vancouver

Linnert M, Iversen HK, Gehl J. Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy. Radiology and Oncology. 2012 Dec;46(4):271-8. https://doi.org/10.2478/v10019-012-0042-y

Author

Linnert, Mette ; Iversen, Helle Klingenberg ; Gehl, Julie. / Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy. In: Radiology and Oncology. 2012 ; Vol. 46, No. 4. pp. 271-8.

Bibtex

@article{c5cbe2f5dc1247c59a01b80c7f70e9d3,
title = "Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy",
abstract = "BACKGROUND: Due to the advanced oncological treatments of cancer, an overall increase in cancer incidence, and better diagnostic tools, the incidence of brain metastases is on the rise. This review addresses the current treatment options for patients with multiple brain metastases, presenting electrochemotherapy (ECT) as one of the new experimental treatments for this group of patients.CONCLUSIONS: Neurosurgery, stereotactic surgery, and whole-brain radiotherapy are the evidence-based treatments that can be applied for patients with multiple brain metastases. Treatment with chemotherapy and molecularly targeted agents may also be warranted. Several experimental treatments are emerging, one of which is ECT, an effective cancer treatment comprising electric pulses given by electrodes in the tumor tissue, causing electroporation of the cell membrane, and thereby augmenting uptake and the cytotoxicity of the chemotherapeutic drug bleomycin by 300 times. Preclinical data are promising and the first patient has been treated in an ongoing clinical trial for patients with brain metastases. Perspectives for ECT in the brain include treatment of primary and secondary brain tumors as well as soft tissue metastases elsewhere.",
author = "Mette Linnert and Iversen, {Helle Klingenberg} and Julie Gehl",
year = "2012",
month = dec,
doi = "10.2478/v10019-012-0042-y",
language = "English",
volume = "46",
pages = "271--8",
journal = "Radiology and Oncology",
issn = "1318-2099",
publisher = "Versita",
number = "4",

}

RIS

TY - JOUR

T1 - Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy

AU - Linnert, Mette

AU - Iversen, Helle Klingenberg

AU - Gehl, Julie

PY - 2012/12

Y1 - 2012/12

N2 - BACKGROUND: Due to the advanced oncological treatments of cancer, an overall increase in cancer incidence, and better diagnostic tools, the incidence of brain metastases is on the rise. This review addresses the current treatment options for patients with multiple brain metastases, presenting electrochemotherapy (ECT) as one of the new experimental treatments for this group of patients.CONCLUSIONS: Neurosurgery, stereotactic surgery, and whole-brain radiotherapy are the evidence-based treatments that can be applied for patients with multiple brain metastases. Treatment with chemotherapy and molecularly targeted agents may also be warranted. Several experimental treatments are emerging, one of which is ECT, an effective cancer treatment comprising electric pulses given by electrodes in the tumor tissue, causing electroporation of the cell membrane, and thereby augmenting uptake and the cytotoxicity of the chemotherapeutic drug bleomycin by 300 times. Preclinical data are promising and the first patient has been treated in an ongoing clinical trial for patients with brain metastases. Perspectives for ECT in the brain include treatment of primary and secondary brain tumors as well as soft tissue metastases elsewhere.

AB - BACKGROUND: Due to the advanced oncological treatments of cancer, an overall increase in cancer incidence, and better diagnostic tools, the incidence of brain metastases is on the rise. This review addresses the current treatment options for patients with multiple brain metastases, presenting electrochemotherapy (ECT) as one of the new experimental treatments for this group of patients.CONCLUSIONS: Neurosurgery, stereotactic surgery, and whole-brain radiotherapy are the evidence-based treatments that can be applied for patients with multiple brain metastases. Treatment with chemotherapy and molecularly targeted agents may also be warranted. Several experimental treatments are emerging, one of which is ECT, an effective cancer treatment comprising electric pulses given by electrodes in the tumor tissue, causing electroporation of the cell membrane, and thereby augmenting uptake and the cytotoxicity of the chemotherapeutic drug bleomycin by 300 times. Preclinical data are promising and the first patient has been treated in an ongoing clinical trial for patients with brain metastases. Perspectives for ECT in the brain include treatment of primary and secondary brain tumors as well as soft tissue metastases elsewhere.

U2 - 10.2478/v10019-012-0042-y

DO - 10.2478/v10019-012-0042-y

M3 - Journal article

C2 - 23412694

VL - 46

SP - 271

EP - 278

JO - Radiology and Oncology

JF - Radiology and Oncology

SN - 1318-2099

IS - 4

ER -

ID: 128982398