MYO-MRI diagnostic protocols in genetic myopathies
Research output: Contribution to journal › Review › Research › peer-review
Whole-body magnetic resonance imaging has emerged as a useful imaging tool in diagnosing and characterizing the progression of myopathies and muscular dystrophies. Whole-body MRI indications and diagnostic efficacy are becoming better defined with the increasing number of cases, publications and discussions within multidisciplinary working groups. Advanced Whole-body MRI protocols are rapid, lower cost, and well-tolerated by patients. Accurate interpretation of muscle Whole-body MRI requires a detailed knowledge of muscle anatomy and differential pattern of involvement in muscle diseases. With the surge in recently identified novel genetic myopathies, Whole-body MRI will become increasingly useful for phenotypic validation of genetic variants of unknown significance. In addition, Whole-body MRI will be progressively used as a biomarker for disease progression and quantify response to therapy with the emergence of novel disease modifying treatments. This review outlines Whole-body MRI indications and updates refined protocols and provides a comprehensive overview of the diagnostic utility and suggested methodology of Whole-body MRI for pediatric and adult patients with muscle diseases.
Original language | English |
---|---|
Journal | Neuromuscular Disorders |
Volume | 29 |
Issue number | 11 |
Pages (from-to) | 827-841 |
ISSN | 0960-8966 |
DOIs | |
Publication status | Published - Nov 2019 |
- Congenital myopathy, Inflammatory myopathy, Inherited myopathy, Limb girdle muscular dystrophy, Magnetic resonance imaging, Whole-body MRI
Research areas
ID: 240244705