Neural correlates of improved recognition of happy faces after erythropoietin treatment in bipolar disorder
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Neural correlates of improved recognition of happy faces after erythropoietin treatment in bipolar disorder. / Miskowiak, Kamilla Woznica; Petersen, N A; Harmer, C J; Ehrenreich, E; Kessing, Lars Vedel; Vinberg, Maj; Macoveanu, Julian; Siebner, Hartwig Roman.
In: Acta Psychiatrica Scandinavica, Vol. 138, No. 4, 10.2018, p. 336-347.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neural correlates of improved recognition of happy faces after erythropoietin treatment in bipolar disorder
AU - Miskowiak, Kamilla Woznica
AU - Petersen, N A
AU - Harmer, C J
AU - Ehrenreich, E
AU - Kessing, Lars Vedel
AU - Vinberg, Maj
AU - Macoveanu, Julian
AU - Siebner, Hartwig Roman
N1 - © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2018/10
Y1 - 2018/10
N2 - OBJECTIVE: Bipolar disorder is associated with impairments in social cognition including the recognition of happy faces. This is accompanied by imbalanced cortico-limbic response to emotional faces. We found that EPO improved the recognition of happy faces in patients with bipolar disorder. This randomized, controlled, longitudinal fMRI study explores the neuronal underpinnings of this effect.METHOD: Forty-four patients with bipolar disorder in full or partial remission were randomized to eight weekly erythropoietin (EPO; 40 000 IU) or saline (NaCl 0.9%) infusions in a double-blind, parallel-group design. Participants underwent whole-brain fMRI at 3T, mood ratings and blood tests at baseline and week 14. During fMRI, participants viewed happy and fearful faces and performed a gender discrimination task.RESULTS: Thirty-four patients had complete pre- and post-treatment fMRI data (EPO: N = 18, saline: N = 16). Erythropoietin vs. saline increased right superior frontal response to happy vs. fearful faces. This correlated with improved happiness recognition in the EPO group. Erythropoietin also enhanced gender discrimination accuracy for happy faces. These effects were not influenced by medication, mood, red blood cells or blood pressure.CONCLUSIONS: Together with previous findings, the present observation suggests that increased dorsal prefrontal attention control is a common mechanism of EPO-associated improvements across several cognitive domains.
AB - OBJECTIVE: Bipolar disorder is associated with impairments in social cognition including the recognition of happy faces. This is accompanied by imbalanced cortico-limbic response to emotional faces. We found that EPO improved the recognition of happy faces in patients with bipolar disorder. This randomized, controlled, longitudinal fMRI study explores the neuronal underpinnings of this effect.METHOD: Forty-four patients with bipolar disorder in full or partial remission were randomized to eight weekly erythropoietin (EPO; 40 000 IU) or saline (NaCl 0.9%) infusions in a double-blind, parallel-group design. Participants underwent whole-brain fMRI at 3T, mood ratings and blood tests at baseline and week 14. During fMRI, participants viewed happy and fearful faces and performed a gender discrimination task.RESULTS: Thirty-four patients had complete pre- and post-treatment fMRI data (EPO: N = 18, saline: N = 16). Erythropoietin vs. saline increased right superior frontal response to happy vs. fearful faces. This correlated with improved happiness recognition in the EPO group. Erythropoietin also enhanced gender discrimination accuracy for happy faces. These effects were not influenced by medication, mood, red blood cells or blood pressure.CONCLUSIONS: Together with previous findings, the present observation suggests that increased dorsal prefrontal attention control is a common mechanism of EPO-associated improvements across several cognitive domains.
KW - bipolar disorder
KW - neurocognition
KW - neuroimaging
KW - randomized controlled trial
U2 - 10.1111/acps.12915
DO - 10.1111/acps.12915
M3 - Journal article
C2 - 29882276
VL - 138
SP - 336
EP - 347
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 4
ER -
ID: 203247935