Neurocognitive heterogeneity in patients with bipolar disorder and their unaffected relatives: associations with emotional cognition
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Neurocognitive heterogeneity in patients with bipolar disorder and their unaffected relatives : associations with emotional cognition. / Kjærstad, Hanne Lie; Eikeseth, Fillip Ferreira; Vinberg, Maj; Kessing, Lars Vedel; Miskowiak, Kamilla.
In: Psychological Medicine, Vol. 51, No. 4, 2021, p. 668-679.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neurocognitive heterogeneity in patients with bipolar disorder and their unaffected relatives
T2 - associations with emotional cognition
AU - Kjærstad, Hanne Lie
AU - Eikeseth, Fillip Ferreira
AU - Vinberg, Maj
AU - Kessing, Lars Vedel
AU - Miskowiak, Kamilla
PY - 2021
Y1 - 2021
N2 - BackgroundRecent evidence suggests that neurocognitive impairments in remitted patients with bipolar disorder (BD) are heterogeneous. Our study aims to replicate recent findings of neurocognitive subgroups, and further explore whether these are related to impairments in affective cognition, in a large sample of remitted patients recently diagnosed with BD and their unaffected relatives compared to healthy controls (HCs).MethodsHierarchal cluster analysis was conducted using neurocognitive data from remitted patients with BD (n = 158). Relatives of patients with BD (n = 52) were categorised into groups consistent with their affected relative's cluster assignment. The neurocognitive clusters of patients with BD and relatives, respectively, were compared with HCs (n = 110) in neurocognition and affective cognition (i.e. emotion processing and regulation).ResultsThree discrete neurocognitive clusters were identified in patients with BD: a globally impaired (23.4%), a selectively impaired (31.0%) and a cognitively intact cluster (45.6%). The neurocognitive subgroups differed in affective cognition, with patients categorised as globally impaired exhibited most impairments in facial expression recognition and emotion regulation in social scenarios. First-degree relatives of cognitively impaired patients displayed impaired facial expression recognition but no impairments in non-emotional cognition.ConclusionsIn a clinical sample of remitted patients recently diagnosed with BD 54.4% had either global or selective cognitive impairment, replicating results of previous studies in patients with longer illness duration. The results suggest that patterns of neurocognition are associated with differential impairments in affective cognition. Aberrant affective cognition in relatives of patients categorised as neurocognitively impaired indicates an inherited risk for BD.
AB - BackgroundRecent evidence suggests that neurocognitive impairments in remitted patients with bipolar disorder (BD) are heterogeneous. Our study aims to replicate recent findings of neurocognitive subgroups, and further explore whether these are related to impairments in affective cognition, in a large sample of remitted patients recently diagnosed with BD and their unaffected relatives compared to healthy controls (HCs).MethodsHierarchal cluster analysis was conducted using neurocognitive data from remitted patients with BD (n = 158). Relatives of patients with BD (n = 52) were categorised into groups consistent with their affected relative's cluster assignment. The neurocognitive clusters of patients with BD and relatives, respectively, were compared with HCs (n = 110) in neurocognition and affective cognition (i.e. emotion processing and regulation).ResultsThree discrete neurocognitive clusters were identified in patients with BD: a globally impaired (23.4%), a selectively impaired (31.0%) and a cognitively intact cluster (45.6%). The neurocognitive subgroups differed in affective cognition, with patients categorised as globally impaired exhibited most impairments in facial expression recognition and emotion regulation in social scenarios. First-degree relatives of cognitively impaired patients displayed impaired facial expression recognition but no impairments in non-emotional cognition.ConclusionsIn a clinical sample of remitted patients recently diagnosed with BD 54.4% had either global or selective cognitive impairment, replicating results of previous studies in patients with longer illness duration. The results suggest that patterns of neurocognition are associated with differential impairments in affective cognition. Aberrant affective cognition in relatives of patients categorised as neurocognitively impaired indicates an inherited risk for BD.
KW - Bipolar disorder
KW - Cognition
KW - Cognitive heterogeneity
KW - Cognitive impairment
KW - Endophenotype
KW - Newly diagnosed
KW - relatives
U2 - 10.1017/S0033291719003738
DO - 10.1017/S0033291719003738
M3 - Journal article
C2 - 31875793
AN - SCOPUS:85077241387
VL - 51
SP - 668
EP - 679
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
IS - 4
ER -
ID: 240629318