Neurovascular coupling in relation to cortical spreading depression
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Neurovascular coupling in relation to cortical spreading depression. / Piilgaard, Henning; Lauritzen, Martin.
In: Neuromethods, Vol. 88, 2014, p. 273-286.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neurovascular coupling in relation to cortical spreading depression
AU - Piilgaard, Henning
AU - Lauritzen, Martin
PY - 2014
Y1 - 2014
N2 - Cortical spreading depression (SD) has been known for more than 70 years. It has been a unique method investigating basic neurophysiology. A growing body of evidence indicates SD is involved in clinical conditions such as migraine with aura, subarachnoid hemorrhage, and traumatic brain injury. In this chapter we describe the application of SD in studying neurovascular and neurometabolic coupling in rat cerebral cortex. Description of the different techniques (electrophysiology, laser-Doppler flowmetry, and oxygen-sensitive electrodes) is followed by in depth step-by-step instructions on how to use them. This chapter will also describe the vascular consequences of SD and how to elicit SD experimentally.
AB - Cortical spreading depression (SD) has been known for more than 70 years. It has been a unique method investigating basic neurophysiology. A growing body of evidence indicates SD is involved in clinical conditions such as migraine with aura, subarachnoid hemorrhage, and traumatic brain injury. In this chapter we describe the application of SD in studying neurovascular and neurometabolic coupling in rat cerebral cortex. Description of the different techniques (electrophysiology, laser-Doppler flowmetry, and oxygen-sensitive electrodes) is followed by in depth step-by-step instructions on how to use them. This chapter will also describe the vascular consequences of SD and how to elicit SD experimentally.
KW - In vivo
KW - Laser-Doppler flowmetry
KW - Local field potential
KW - Neurometabolic coupling
KW - Neurovascular coupling
KW - Oxygen-sensitive electrodes
KW - Spreading depression
U2 - 10.1007/978-1-4939-0724-3_14
DO - 10.1007/978-1-4939-0724-3_14
M3 - Journal article
AN - SCOPUS:84927612123
VL - 88
SP - 273
EP - 286
JO - Neuromethods
JF - Neuromethods
SN - 0893-2336
ER -
ID: 200873265