On the possible relation of spreading cortical depression to classical migraine.
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On the possible relation of spreading cortical depression to classical migraine. / Lauritzen, M.
In: Cephalalgia : an international journal of headache, Vol. 5 Suppl 2, 01.01.1985, p. 47-51.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - On the possible relation of spreading cortical depression to classical migraine.
AU - Lauritzen, M.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - During the first 1 to 2 h of the classical migraine attack a hypoperfusion develops which starts in the posterior part of the brain and progresses anteriorly at a rate of 2-3 mm/min. The hypoperfusion stops at primary sulci outlining major cortical macro- and microstructural changes, but seems not to be inhibited by other changes of the cortical architecture. The low flow regions are cortical and the low flow persists for 4-6 h, until the attack abates. Regions of hyperperfusion are either minor or non-existent. A similar behavior characterizes the velocity and mode of evolution of a cortical spreading depression, a transient perturbation of cortical neuronal function which has profound and long-lasting influence on the cortical blood flow. This paper briefly summarizes the arguments which have been put forward in recent years suggesting that spreading depression is a pathogenetic mechanism of migraine.
AB - During the first 1 to 2 h of the classical migraine attack a hypoperfusion develops which starts in the posterior part of the brain and progresses anteriorly at a rate of 2-3 mm/min. The hypoperfusion stops at primary sulci outlining major cortical macro- and microstructural changes, but seems not to be inhibited by other changes of the cortical architecture. The low flow regions are cortical and the low flow persists for 4-6 h, until the attack abates. Regions of hyperperfusion are either minor or non-existent. A similar behavior characterizes the velocity and mode of evolution of a cortical spreading depression, a transient perturbation of cortical neuronal function which has profound and long-lasting influence on the cortical blood flow. This paper briefly summarizes the arguments which have been put forward in recent years suggesting that spreading depression is a pathogenetic mechanism of migraine.
UR - http://www.scopus.com/inward/record.url?scp=0022065776&partnerID=8YFLogxK
U2 - 10.1177/03331024850050S208
DO - 10.1177/03331024850050S208
M3 - Journal article
C2 - 4016941
AN - SCOPUS:0022065776
VL - 5 Suppl 2
SP - 47
EP - 51
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
ER -
ID: 201457932