Pleocytosis in cerebrospinal fluid attributed to ischemic stroke: A review of the literature
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Pleocytosis in cerebrospinal fluid attributed to ischemic stroke : A review of the literature. / Rundblad, Lucas Ivan Sebastian; Iversen, Helle K.; West, Anders S.
In: Journal of the Neurological Sciences, Vol. 449, 120664, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Pleocytosis in cerebrospinal fluid attributed to ischemic stroke
T2 - A review of the literature
AU - Rundblad, Lucas Ivan Sebastian
AU - Iversen, Helle K.
AU - West, Anders S.
N1 - Publisher Copyright: © 2023
PY - 2023
Y1 - 2023
N2 - Introduction: Lumbar puncture is generally performed in stroke settings when infectious or inflammatory diseases are suspected to be the etiology. This review aimed to assess the prevalence of pleocytosis in the cerebrospinal fluid following ischemic stroke without inflammatory or infectious etiology. Methods: We searched PubMed for studies with mentions of “[ischemic stroke] AND [cerebrospinal fluid]”. We included only studies written in English, including patients with a primary diagnosis of either ischemic stroke or transient ischemic attack (TIA), and where white blood cell count in the spinal fluid was presented. Studies investigating common etiologies for pleocytosis, was excluded. Study and patient characteristics, white blood cell count and time to lumbar puncture were presented in tables, and the prevalence of pleocytosis were reported and plotted graphically. Results: We included 15 studies with 1607 patients, 1522 with ischemic stroke and 85 with TIA. The prevalence of pleocytosis was between 0% to 28,6% and a mean of 11.8%. The highest white blood cell count found with common etiologies for pleocytosis ruled out was 56 cells/mm3. A mean white blood cell count of 4.0 was based on the three studies where this was available. Discussion: The included studies were methodologically heterogenous and few had pleocytosis as primary outcome. Pleocytosis following ischemic stroke is uncommon and should prompt further investigations
AB - Introduction: Lumbar puncture is generally performed in stroke settings when infectious or inflammatory diseases are suspected to be the etiology. This review aimed to assess the prevalence of pleocytosis in the cerebrospinal fluid following ischemic stroke without inflammatory or infectious etiology. Methods: We searched PubMed for studies with mentions of “[ischemic stroke] AND [cerebrospinal fluid]”. We included only studies written in English, including patients with a primary diagnosis of either ischemic stroke or transient ischemic attack (TIA), and where white blood cell count in the spinal fluid was presented. Studies investigating common etiologies for pleocytosis, was excluded. Study and patient characteristics, white blood cell count and time to lumbar puncture were presented in tables, and the prevalence of pleocytosis were reported and plotted graphically. Results: We included 15 studies with 1607 patients, 1522 with ischemic stroke and 85 with TIA. The prevalence of pleocytosis was between 0% to 28,6% and a mean of 11.8%. The highest white blood cell count found with common etiologies for pleocytosis ruled out was 56 cells/mm3. A mean white blood cell count of 4.0 was based on the three studies where this was available. Discussion: The included studies were methodologically heterogenous and few had pleocytosis as primary outcome. Pleocytosis following ischemic stroke is uncommon and should prompt further investigations
KW - Cerebrospinal fluid
KW - Ischemic stroke
KW - Pleocytosis
KW - Transient ischemic attack
KW - White blood cells
U2 - 10.1016/j.jns.2023.120664
DO - 10.1016/j.jns.2023.120664
M3 - Review
C2 - 37119718
AN - SCOPUS:85153510151
VL - 449
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
M1 - 120664
ER -
ID: 365552986