Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder: A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder : A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees. / Uldall, Sigurd W.; Madsen, Kristoffer H.; Siebner, Hartwig R.; Lanius, Ruth; Frewen, Paul; Fischer, Elvira; Madsen, Camilla G.; Leffers, Anne Mette; Rostrup, Egill; Carlsson, Jessica L.; Nejad, Ayna B.

In: Chronic Stress, Vol. 4, 01.2020, p. 1-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Uldall, SW, Madsen, KH, Siebner, HR, Lanius, R, Frewen, P, Fischer, E, Madsen, CG, Leffers, AM, Rostrup, E, Carlsson, JL & Nejad, AB 2020, 'Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder: A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees', Chronic Stress, vol. 4, pp. 1-11. https://doi.org/10.1177/2470547020917623

APA

Uldall, S. W., Madsen, K. H., Siebner, H. R., Lanius, R., Frewen, P., Fischer, E., Madsen, C. G., Leffers, A. M., Rostrup, E., Carlsson, J. L., & Nejad, A. B. (2020). Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder: A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees. Chronic Stress, 4, 1-11. https://doi.org/10.1177/2470547020917623

Vancouver

Uldall SW, Madsen KH, Siebner HR, Lanius R, Frewen P, Fischer E et al. Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder: A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees. Chronic Stress. 2020 Jan;4:1-11. https://doi.org/10.1177/2470547020917623

Author

Uldall, Sigurd W. ; Madsen, Kristoffer H. ; Siebner, Hartwig R. ; Lanius, Ruth ; Frewen, Paul ; Fischer, Elvira ; Madsen, Camilla G. ; Leffers, Anne Mette ; Rostrup, Egill ; Carlsson, Jessica L. ; Nejad, Ayna B. / Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder : A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees. In: Chronic Stress. 2020 ; Vol. 4. pp. 1-11.

Bibtex

@article{3bebd986ea614fd2bbe74fed8165386d,
title = "Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder: A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees",
abstract = "Background: Symptoms of anhedonia are often central to posttraumatic stress disorder (PTSD), but it is unclear how anhedonia is affected by processes induced by reliving past traumatic memories. Methods: Sixty-nine male refugees (PTSD = 38) were interviewed and scanned with functional magnetic resonance imaging while viewing positive, neutral and Scrambled Pictures after being read personalized scripts evoking an emotionally neutral memory and a traumatic memory. We further measured postprovocation state symptoms, physiological measures and PTSD symptoms. We tested whether neural activity associated with positive picture viewing in participants with PTSD was differentially affected by symptom provocation compared to controls. Results: For the pictures > scrambled contrast (Positive contrast), PTSD participants had significantly less activity than controls in fusiform gyrus, right inferior temporal gyrus and left middle occipital gyrus. The Positive contrast activity in fusiform gyrus scaled negatively with anhedonia symptoms in PTSD participants after controlling for total PTSD severity. Relative to the emotionally Neutral Script, the Trauma Script decreased positive picture viewing activity in posterior cingulate cortex, precuneus and left calcarine gyrus, but there was no difference between PTSD participants and controls. Conclusions: We found reduced responsiveness of higher visual processing of emotionally positive pictures in PTSD. The significant correlation found between positive picture viewing activity and anhedonia suggests the reduced responsiveness to be due to the severity of anhedonia.",
keywords = "anhedonia, emotional numbness, functional magnetic resonance imaging, posttraumatic stress disorder, symptom provocation, visual stimuli",
author = "Uldall, {Sigurd W.} and Madsen, {Kristoffer H.} and Siebner, {Hartwig R.} and Ruth Lanius and Paul Frewen and Elvira Fischer and Madsen, {Camilla G.} and Leffers, {Anne Mette} and Egill Rostrup and Carlsson, {Jessica L.} and Nejad, {Ayna B.}",
year = "2020",
month = jan,
doi = "10.1177/2470547020917623",
language = "English",
volume = "4",
pages = "1--11",
journal = "Chronic Stress",
issn = "2470-5470",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder

T2 - A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees

AU - Uldall, Sigurd W.

AU - Madsen, Kristoffer H.

AU - Siebner, Hartwig R.

AU - Lanius, Ruth

AU - Frewen, Paul

AU - Fischer, Elvira

AU - Madsen, Camilla G.

AU - Leffers, Anne Mette

AU - Rostrup, Egill

AU - Carlsson, Jessica L.

AU - Nejad, Ayna B.

PY - 2020/1

Y1 - 2020/1

N2 - Background: Symptoms of anhedonia are often central to posttraumatic stress disorder (PTSD), but it is unclear how anhedonia is affected by processes induced by reliving past traumatic memories. Methods: Sixty-nine male refugees (PTSD = 38) were interviewed and scanned with functional magnetic resonance imaging while viewing positive, neutral and Scrambled Pictures after being read personalized scripts evoking an emotionally neutral memory and a traumatic memory. We further measured postprovocation state symptoms, physiological measures and PTSD symptoms. We tested whether neural activity associated with positive picture viewing in participants with PTSD was differentially affected by symptom provocation compared to controls. Results: For the pictures > scrambled contrast (Positive contrast), PTSD participants had significantly less activity than controls in fusiform gyrus, right inferior temporal gyrus and left middle occipital gyrus. The Positive contrast activity in fusiform gyrus scaled negatively with anhedonia symptoms in PTSD participants after controlling for total PTSD severity. Relative to the emotionally Neutral Script, the Trauma Script decreased positive picture viewing activity in posterior cingulate cortex, precuneus and left calcarine gyrus, but there was no difference between PTSD participants and controls. Conclusions: We found reduced responsiveness of higher visual processing of emotionally positive pictures in PTSD. The significant correlation found between positive picture viewing activity and anhedonia suggests the reduced responsiveness to be due to the severity of anhedonia.

AB - Background: Symptoms of anhedonia are often central to posttraumatic stress disorder (PTSD), but it is unclear how anhedonia is affected by processes induced by reliving past traumatic memories. Methods: Sixty-nine male refugees (PTSD = 38) were interviewed and scanned with functional magnetic resonance imaging while viewing positive, neutral and Scrambled Pictures after being read personalized scripts evoking an emotionally neutral memory and a traumatic memory. We further measured postprovocation state symptoms, physiological measures and PTSD symptoms. We tested whether neural activity associated with positive picture viewing in participants with PTSD was differentially affected by symptom provocation compared to controls. Results: For the pictures > scrambled contrast (Positive contrast), PTSD participants had significantly less activity than controls in fusiform gyrus, right inferior temporal gyrus and left middle occipital gyrus. The Positive contrast activity in fusiform gyrus scaled negatively with anhedonia symptoms in PTSD participants after controlling for total PTSD severity. Relative to the emotionally Neutral Script, the Trauma Script decreased positive picture viewing activity in posterior cingulate cortex, precuneus and left calcarine gyrus, but there was no difference between PTSD participants and controls. Conclusions: We found reduced responsiveness of higher visual processing of emotionally positive pictures in PTSD. The significant correlation found between positive picture viewing activity and anhedonia suggests the reduced responsiveness to be due to the severity of anhedonia.

KW - anhedonia

KW - emotional numbness

KW - functional magnetic resonance imaging

KW - posttraumatic stress disorder

KW - symptom provocation

KW - visual stimuli

U2 - 10.1177/2470547020917623

DO - 10.1177/2470547020917623

M3 - Journal article

C2 - 32518887

AN - SCOPUS:85084580967

VL - 4

SP - 1

EP - 11

JO - Chronic Stress

JF - Chronic Stress

SN - 2470-5470

ER -

ID: 243908085