TY - JOUR

T1 - Psychedelic resting-state neuroimaging

T2 - A review and perspective on balancing replication and novel analyses

AU - McCulloch, Drummond E.Wen

AU - Knudsen, Gitte Moos

AU - Barrett, Frederick Streeter

AU - Doss, Manoj K.

AU - Carhart-Harris, Robin Lester

AU - Rosas, Fernando E.

AU - Deco, Gustavo

AU - Kringelbach, Morten L.

AU - Preller, Katrin H.

AU - Ramaekers, Johannes G.

AU - Mason, Natasha L.

AU - Müller, Felix

AU - Fisher, Patrick Mac Donald

N1 - Publisher Copyright: © 2022 The Authors

PY - 2022

Y1 - 2022

N2 - Clinical research into serotonergic psychedelics is expanding rapidly, showing promising efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs-fMRI) is a commonly used strategy to identify psychedelic-induced changes in neural pathways in clinical and healthy populations. Here we, a large group of psychedelic imaging researchers, review the 42 research articles published to date, based on the 17 unique studies evaluating psychedelic effects on rs-fMRI, focusing on methodological variation. Prominently, we observe that nearly all studies vary in data processing and analysis methodology, two datasets are the foundation of over half of the published literature, and there is lexical ambiguity in common outcome metric terminology. We offer guidelines for future studies that encourage coherence in the field. Psychedelic rs-fMRI will benefit from the development of novel methods that expand our understanding of the brain mechanisms mediating its intriguing effects; yet, this field is at a crossroads where we must also consider the critical importance of consistency and replicability to effectively converge on stable representations of the neural effects of psychedelics.

AB - Clinical research into serotonergic psychedelics is expanding rapidly, showing promising efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs-fMRI) is a commonly used strategy to identify psychedelic-induced changes in neural pathways in clinical and healthy populations. Here we, a large group of psychedelic imaging researchers, review the 42 research articles published to date, based on the 17 unique studies evaluating psychedelic effects on rs-fMRI, focusing on methodological variation. Prominently, we observe that nearly all studies vary in data processing and analysis methodology, two datasets are the foundation of over half of the published literature, and there is lexical ambiguity in common outcome metric terminology. We offer guidelines for future studies that encourage coherence in the field. Psychedelic rs-fMRI will benefit from the development of novel methods that expand our understanding of the brain mechanisms mediating its intriguing effects; yet, this field is at a crossroads where we must also consider the critical importance of consistency and replicability to effectively converge on stable representations of the neural effects of psychedelics.

KW - Ayahausca

KW - Clinical

KW - DMT

KW - Entheogen

KW - FMRI

KW - Hallucinogen

KW - Human

KW - LSD

KW - Neuroimaging

KW - Psilocin

KW - Psilocybin

KW - Psychedelic

KW - Replication

KW - Resting-state

KW - Serotonin

U2 - 10.1016/j.neubiorev.2022.104689

DO - 10.1016/j.neubiorev.2022.104689

M3 - Review

C2 - 35588933

AN - SCOPUS:85131443757

VL - 138

JO - Neuroscience & Biobehavioral Reviews

JF - Neuroscience & Biobehavioral Reviews

SN - 0149-7634

M1 - 104689

ER -