Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine
Research output: Contribution to journal › Journal article › Research › peer-review
Several dopamine D(2) agonist radioligands have been used with positron emission tomography (PET), including [(11)C-]-(-)-MNPA, [(11)C-]-(-)-NPA and [(11)C]-(+)-PHNO. These radioligands are considered particularly powerful for detection of endogenous dopamine release, but they either provide PET brain images with limited contrast or have affinity for both D(2) and D(3) receptors. We here present the carbon-11 radiolabeling and ex vivo evaluation of 2-Cl-(-)-NPA, a novel PET-tracer candidate with high in vitro D(2)/D(3) selectivity.
Original language | English |
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Journal | Nuclear Medicine and Biology |
Volume | 37 |
Issue number | 1 |
Pages (from-to) | 35-40 |
Number of pages | 6 |
ISSN | 0969-8051 |
DOIs | |
Publication status | Published - 1 Jan 2010 |
ID: 34143118