Regional density of perfused capillaries and cerebral blood flow in untreated short-term and long-term streptozotocin diabetes
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The regional density of perfused cerebral capillaries (rDPC) and regional cerebral blood flow (rCBF) were measured in 12 selected brain regions in rats after 3 and 20 weeks of streptozotocin-induced diabetes and in control groups. After 3 weeks of diabetes, both rCBF and rDPC were unchanged in the diabetic group compared to the control group. A diabetes duration of 20 weeks causing bilateral cataracts induced a significant (p less than 0.05) reduction in rCBF in two structures in the visual system compared to the control group (visual cortex: 105 versus 129 ml 100 g-1 min-1; lateral geniculate body: 106 versus 128 ml 100 g-1 min-1) and in the pontine reticular nucleus (82 versus 128 ml 100 g min-1), whereas rDPC remained unchanged. A highly significant correlation between rCBF and rDPC was found in both control groups (r = 0.8, p less than 0.005) whereas the correlation was more scattered in the diabetic groups (r = 0.6, p less than 0.05). The present results show that during chronic diabetes, a reduction of rCBF does not affect the number of perfused capillaries.
Original language | English |
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Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 11 |
Issue number | 3 |
Pages (from-to) | 361-5 |
Number of pages | 5 |
ISSN | 0271-678X |
DOIs | |
Publication status | Published - May 1991 |
- Animals, Capillaries/pathology, Cataract/etiology, Cerebrovascular Circulation, Diabetes Mellitus, Experimental/complications, Geniculate Bodies/blood supply, Male, Pons/blood supply, Rats, Rats, Inbred Strains, Time Factors, Visual Cortex/blood supply
Research areas
ID: 275029456