Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT
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Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT. / Ziebell, Morten; Thomsen, Gerda; Knudsen, Gitte M; de Nijs, Robin; Svarer, Claus; Wagner, Aase; Pinborg, Lars H.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 34, No. 1, 01.01.2007, p. 101-9.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT
AU - Ziebell, Morten
AU - Thomsen, Gerda
AU - Knudsen, Gitte M
AU - de Nijs, Robin
AU - Svarer, Claus
AU - Wagner, Aase
AU - Pinborg, Lars H
PY - 2007/1/1
Y1 - 2007/1/1
N2 - The iodinated cocaine derivative [(123)I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [(123)I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119-271]. The aims of this study were, firstly, to evaluate the test-retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, BP(1) (C(ROI)/C(plasma)) and BP(2) (C(ROI)/C(REF)).
AB - The iodinated cocaine derivative [(123)I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with SPECT. Recently, a bolus/infusion (B/I) protocol for [(123)I]PE2I measurements of DAT density was established [Pinborg LH et al. J Nucl Med 2005;46:1119-271]. The aims of this study were, firstly, to evaluate the test-retest variability using the B/I protocol and, secondly, to evaluate the B/I approach in a new group of healthy subjects using two outcome parameters, BP(1) (C(ROI)/C(plasma)) and BP(2) (C(ROI)/C(REF)).
U2 - http://dx.doi.org/10.1007/s00259-006-0161-z
DO - http://dx.doi.org/10.1007/s00259-006-0161-z
M3 - Journal article
VL - 34
SP - 101
EP - 109
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
SN - 1619-7070
IS - 1
ER -
ID: 34094258