Serotonergic mechanisms in the migraine brain: a systematic review
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Serotonergic mechanisms in the migraine brain : a systematic review. / Christensen, Marie Deen; Christensen, Casper Emil; Hougaard, Anders; Hansen, Hanne Demant; Knudsen, Gitte Moos; Ashina, Messoud.
In: Cephalalgia : an international journal of headache, Vol. 37, No. 3, 03.2017, p. 251-264.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Serotonergic mechanisms in the migraine brain
T2 - a systematic review
AU - Christensen, Marie Deen
AU - Christensen, Casper Emil
AU - Hougaard, Anders
AU - Hansen, Hanne Demant
AU - Knudsen, Gitte Moos
AU - Ashina, Messoud
PY - 2017/3
Y1 - 2017/3
N2 - Background Migraine is one of the most common and disabling of all medical conditions, affecting 16% of the general population, causing huge socioeconomic costs globally. Current available treatment options are inadequate. Serotonin is a key molecule in the neurobiology of migraine, but the exact role of brain serotonergic mechanisms remains a matter of controversy. Methods We systematically searched PubMed for studies investigating the serotonergic system in the migraine brain by either molecular neuroimaging or electrophysiological methods. Results The literature search resulted in 59 papers, of which 13 were eligible for review. The reviewed papers collectively support the notion that migraine patients have alterations in serotonergic neurotransmission. Most likely, migraine patients have a low cerebral serotonin level between attacks, which elevates during a migraine attack. Conclusion This review suggests that novel methods of investigating the serotonergic system in the migraine brain are warranted. Uncovering the serotonergic mechanisms in migraine pathophysiology could prove useful for the development of future migraine drugs.
AB - Background Migraine is one of the most common and disabling of all medical conditions, affecting 16% of the general population, causing huge socioeconomic costs globally. Current available treatment options are inadequate. Serotonin is a key molecule in the neurobiology of migraine, but the exact role of brain serotonergic mechanisms remains a matter of controversy. Methods We systematically searched PubMed for studies investigating the serotonergic system in the migraine brain by either molecular neuroimaging or electrophysiological methods. Results The literature search resulted in 59 papers, of which 13 were eligible for review. The reviewed papers collectively support the notion that migraine patients have alterations in serotonergic neurotransmission. Most likely, migraine patients have a low cerebral serotonin level between attacks, which elevates during a migraine attack. Conclusion This review suggests that novel methods of investigating the serotonergic system in the migraine brain are warranted. Uncovering the serotonergic mechanisms in migraine pathophysiology could prove useful for the development of future migraine drugs.
KW - Brain
KW - Humans
KW - Migraine Disorders
KW - Serotonin
KW - Journal Article
KW - Review
U2 - 10.1177/0333102416640501
DO - 10.1177/0333102416640501
M3 - Review
C2 - 27013238
VL - 37
SP - 251
EP - 264
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 3
ER -
ID: 179625295