Sixteen Weeks of Aerobic Exercise does not Alter Resting-state Connectivity of the Precuneus in Patients with Alzheimer’s Disease
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Sixteen Weeks of Aerobic Exercise does not Alter Resting-state Connectivity of the Precuneus in Patients with Alzheimer’s Disease. / Musaeus, Christian Sandøe; Johansen, Louise Baruël; Hasselbalch, Steen; Beyer, Nina; Høgh, Peter; Siebner, Hartwig Roman; Frederiksen, Kristian Steen.
In: Current Alzheimer Research, Vol. 19, No. 2, 2022, p. 171-177.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Sixteen Weeks of Aerobic Exercise does not Alter Resting-state Connectivity of the Precuneus in Patients with Alzheimer’s Disease
AU - Musaeus, Christian Sandøe
AU - Johansen, Louise Baruël
AU - Hasselbalch, Steen
AU - Beyer, Nina
AU - Høgh, Peter
AU - Siebner, Hartwig Roman
AU - Frederiksen, Kristian Steen
N1 - Publisher Copyright: © 2022 Bentham Science Publishers.
PY - 2022
Y1 - 2022
N2 - Introduction: In healthy elderly persons and patients with mild cognitive impairment, physical exercise can increase functional brain connectivity in the default mode network (DMN) measured by resting-state functional magnetic resonance imaging (rs-fMRI). However, no studies have so far investigated the effect of physical exercise on functional resting-state connectivity in the DMN in patients with Alzheimer’s disease (AD). Objective: In a single-blinded randomized controlled trial, we assessed the effects of an aerobic exercise intervention of 16 weeks of physical exercise on DMN connectivity using rs-fMRI in patients with AD. Methods: Forty-five patients were randomly assigned to either a control or exercise group. The exercise group performed 60-min of aerobic exercise three times per week for 16 weeks. All the patients underwent whole-brain rs-fMRI at 3 T, at baseline, and after 16 weeks. Since the posterior cingulate cortex (PCC) and adjacent precuneus constitute a central hub of the DMN, this parietal region was defined as region-of-interest and used as the seed region for functional connectivity analysis of the rs-fMRI data treating age and gender as covariates. Results: Neither seed-based analysis, seeded in the PCC/precuneus region nor ICA-based analyses, focusing on components of the DMN network, showed any exercise-induced changes in functional resting-state connectivity from baseline to follow-up. Conclusion: 16 weeks of aerobic exercise does not modify functional connectivity of the PCC/precuneus region in patients with AD. A longer intervention may be needed to show the effect of exercise on brain connec-tivity. Clinical Trial Registration Number: The trial was registered at ClinicalTrials.gov (identifier: NCT01681602) on September 10, 2012.
AB - Introduction: In healthy elderly persons and patients with mild cognitive impairment, physical exercise can increase functional brain connectivity in the default mode network (DMN) measured by resting-state functional magnetic resonance imaging (rs-fMRI). However, no studies have so far investigated the effect of physical exercise on functional resting-state connectivity in the DMN in patients with Alzheimer’s disease (AD). Objective: In a single-blinded randomized controlled trial, we assessed the effects of an aerobic exercise intervention of 16 weeks of physical exercise on DMN connectivity using rs-fMRI in patients with AD. Methods: Forty-five patients were randomly assigned to either a control or exercise group. The exercise group performed 60-min of aerobic exercise three times per week for 16 weeks. All the patients underwent whole-brain rs-fMRI at 3 T, at baseline, and after 16 weeks. Since the posterior cingulate cortex (PCC) and adjacent precuneus constitute a central hub of the DMN, this parietal region was defined as region-of-interest and used as the seed region for functional connectivity analysis of the rs-fMRI data treating age and gender as covariates. Results: Neither seed-based analysis, seeded in the PCC/precuneus region nor ICA-based analyses, focusing on components of the DMN network, showed any exercise-induced changes in functional resting-state connectivity from baseline to follow-up. Conclusion: 16 weeks of aerobic exercise does not modify functional connectivity of the PCC/precuneus region in patients with AD. A longer intervention may be needed to show the effect of exercise on brain connec-tivity. Clinical Trial Registration Number: The trial was registered at ClinicalTrials.gov (identifier: NCT01681602) on September 10, 2012.
KW - Alzheimer’s disease
KW - default mode network
KW - exercise
KW - fMRI
KW - Physical exercise
KW - resting-state
U2 - 10.2174/1567205019666220304091241
DO - 10.2174/1567205019666220304091241
M3 - Journal article
C2 - 35249488
AN - SCOPUS:85131390247
VL - 19
SP - 171
EP - 177
JO - Current Alzheimer Research
JF - Current Alzheimer Research
SN - 1567-2050
IS - 2
ER -
ID: 314062984