Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957. / Palner, Mikael; McCormick, Patrick; Parkes, Jun; Knudsen, Gitte M; Wilson, Alan A.

In: Nuclear Medicine and Biology, Vol. 37, No. 7, 01.10.2010, p. 837-43.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Palner, M, McCormick, P, Parkes, J, Knudsen, GM & Wilson, AA 2010, 'Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957', Nuclear Medicine and Biology, vol. 37, no. 7, pp. 837-43. https://doi.org/10.1016/j.nucmedbio.2010.04.193, https://doi.org/10.1016/j.nucmedbio.2010.04.193

APA

Palner, M., McCormick, P., Parkes, J., Knudsen, G. M., & Wilson, A. A. (2010). Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957. Nuclear Medicine and Biology, 37(7), 837-43. https://doi.org/10.1016/j.nucmedbio.2010.04.193, https://doi.org/10.1016/j.nucmedbio.2010.04.193

Vancouver

Palner M, McCormick P, Parkes J, Knudsen GM, Wilson AA. Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957. Nuclear Medicine and Biology. 2010 Oct 1;37(7):837-43. https://doi.org/10.1016/j.nucmedbio.2010.04.193, https://doi.org/10.1016/j.nucmedbio.2010.04.193

Author

Palner, Mikael ; McCormick, Patrick ; Parkes, Jun ; Knudsen, Gitte M ; Wilson, Alan A. / Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957. In: Nuclear Medicine and Biology. 2010 ; Vol. 37, No. 7. pp. 837-43.

Bibtex

@article{12f5ca4df136454cac1203891d0e0048,
title = "Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957",
abstract = "R-[(11)C]-SKF 82957 is a high-affinity and potent dopamine D(1) receptor agonist radioligand, which gives rise to a brain-penetrant lipophilic metabolite. In this study, we demonstrate that systemic administration of catechol-O-methyl transferase (COMT) inhibitors blocks this metabolic pathway, facilitating the use of R-[(11)C]-SKF 82957 to image the high-affinity state of the dopamine D(1) receptor with PET.",
keywords = "Animals, Benzazepines, Benzophenones, Brain, Carbon Radioisotopes, Catechol O-Methyltransferase, Catechols, Dopamine Agonists, Enzyme Inhibitors, Nitriles, Nitrophenols, Positron-Emission Tomography, Radiopharmaceuticals, Rats, Receptors, Dopamine D1, Tissue Distribution",
author = "Mikael Palner and Patrick McCormick and Jun Parkes and Knudsen, {Gitte M} and Wilson, {Alan A}",
note = "Copyright {\textcopyright} 2010 Elsevier Inc. All rights reserved.",
year = "2010",
month = oct,
day = "1",
doi = "10.1016/j.nucmedbio.2010.04.193",
language = "English",
volume = "37",
pages = "837--43",
journal = "Nuclear Medicine and Biology",
issn = "0969-8051",
publisher = "Elsevier",
number = "7",

}

RIS

TY - JOUR

T1 - Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957

AU - Palner, Mikael

AU - McCormick, Patrick

AU - Parkes, Jun

AU - Knudsen, Gitte M

AU - Wilson, Alan A

N1 - Copyright © 2010 Elsevier Inc. All rights reserved.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - R-[(11)C]-SKF 82957 is a high-affinity and potent dopamine D(1) receptor agonist radioligand, which gives rise to a brain-penetrant lipophilic metabolite. In this study, we demonstrate that systemic administration of catechol-O-methyl transferase (COMT) inhibitors blocks this metabolic pathway, facilitating the use of R-[(11)C]-SKF 82957 to image the high-affinity state of the dopamine D(1) receptor with PET.

AB - R-[(11)C]-SKF 82957 is a high-affinity and potent dopamine D(1) receptor agonist radioligand, which gives rise to a brain-penetrant lipophilic metabolite. In this study, we demonstrate that systemic administration of catechol-O-methyl transferase (COMT) inhibitors blocks this metabolic pathway, facilitating the use of R-[(11)C]-SKF 82957 to image the high-affinity state of the dopamine D(1) receptor with PET.

KW - Animals

KW - Benzazepines

KW - Benzophenones

KW - Brain

KW - Carbon Radioisotopes

KW - Catechol O-Methyltransferase

KW - Catechols

KW - Dopamine Agonists

KW - Enzyme Inhibitors

KW - Nitriles

KW - Nitrophenols

KW - Positron-Emission Tomography

KW - Radiopharmaceuticals

KW - Rats

KW - Receptors, Dopamine D1

KW - Tissue Distribution

U2 - 10.1016/j.nucmedbio.2010.04.193

DO - 10.1016/j.nucmedbio.2010.04.193

M3 - Journal article

C2 - 20870159

VL - 37

SP - 837

EP - 843

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

SN - 0969-8051

IS - 7

ER -

ID: 34142977