Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study
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Task-specific modulation of effective connectivity during two simple unimanual motor tasks : A 122-channel EEG study. / Herz, Damian M; Christensen, Mark Schram; Reck, Christiane; Florin, Esther; Barbe, Michael T; Stahlhut, Carsten; Pauls, K Amande M; Tittgemeyer, Marc; Siebner, Hartwig R; Timmermann, Lars.
In: NeuroImage, Vol. 59, No. 4, 2012, p. 3187-3193.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Task-specific modulation of effective connectivity during two simple unimanual motor tasks
T2 - A 122-channel EEG study
AU - Herz, Damian M
AU - Christensen, Mark Schram
AU - Reck, Christiane
AU - Florin, Esther
AU - Barbe, Michael T
AU - Stahlhut, Carsten
AU - Pauls, K Amande M
AU - Tittgemeyer, Marc
AU - Siebner, Hartwig R
AU - Timmermann, Lars
N1 - CURIS 2012 5200 116
PY - 2012
Y1 - 2012
N2 - Neural oscillations are thought to underlie coupling of spatially remote neurons and gating of information within the human sensorimotor system. Here we tested the hypothesis that different unimanual motor tasks are specifically associated with distinct patterns of oscillatory coupling in human sensorimotor cortical areas. In 13 healthy, right-handed subjects, we recorded task-induced neural activity with 122-channel electroencephalography (EEG) while subjects performed fast self-paced extension-flexion movements with the right index finger and an isometric contraction of the right forearm. Task-related modulations of inter-regional coupling within a core motor network comprising the left primary motor cortex (M1), lateral premotor cortex (lPM) and supplementary motor area (SMA) were then modeled using dynamic causal modeling (DCM). A network model postulating coupling both within and across frequencies best captured observed spectral responses according to Bayesian model selection. DCM revealed dominant coupling within the ß-band (13-30 Hz) between M1 and SMA during isometric contraction of the forearm, whereas fast repetitive finger movements were characterized by strong coupling within the ¿-band (31-48 Hz) and between the ¿- (4-7 Hz) and the ¿-band. This coupling pattern was mainly expressed in connections from lPM to SMA and from lPM to M1. We infer that human manual motor control involves task-specific modulation of inter-regional oscillatory coupling both within and across distinct frequency bands. The results highlight the potential of DCM to characterize context-specific changes in coupling within functional brain networks.
AB - Neural oscillations are thought to underlie coupling of spatially remote neurons and gating of information within the human sensorimotor system. Here we tested the hypothesis that different unimanual motor tasks are specifically associated with distinct patterns of oscillatory coupling in human sensorimotor cortical areas. In 13 healthy, right-handed subjects, we recorded task-induced neural activity with 122-channel electroencephalography (EEG) while subjects performed fast self-paced extension-flexion movements with the right index finger and an isometric contraction of the right forearm. Task-related modulations of inter-regional coupling within a core motor network comprising the left primary motor cortex (M1), lateral premotor cortex (lPM) and supplementary motor area (SMA) were then modeled using dynamic causal modeling (DCM). A network model postulating coupling both within and across frequencies best captured observed spectral responses according to Bayesian model selection. DCM revealed dominant coupling within the ß-band (13-30 Hz) between M1 and SMA during isometric contraction of the forearm, whereas fast repetitive finger movements were characterized by strong coupling within the ¿-band (31-48 Hz) and between the ¿- (4-7 Hz) and the ¿-band. This coupling pattern was mainly expressed in connections from lPM to SMA and from lPM to M1. We infer that human manual motor control involves task-specific modulation of inter-regional oscillatory coupling both within and across distinct frequency bands. The results highlight the potential of DCM to characterize context-specific changes in coupling within functional brain networks.
KW - Adolescent
KW - Adult
KW - Electroencephalography
KW - Female
KW - Fingers
KW - Humans
KW - Isometric Contraction
KW - Male
KW - Motor Cortex
KW - Nervous System Physiological Processes
KW - Task Performance and Analysis
KW - Young Adult
U2 - 10.1016/j.neuroimage.2011.11.042
DO - 10.1016/j.neuroimage.2011.11.042
M3 - Journal article
C2 - 22146753
VL - 59
SP - 3187
EP - 3193
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 4
ER -
ID: 40381683