TY - JOUR

T1 - The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls

AU - Thorup, Anne Amalie Elgaard

AU - Hemager, Nicoline

AU - Bliksted, Vibeke Fuglsang

AU - Greve, Aja Neergaard

AU - Ohland, Jessica

AU - Wilms, Martin

AU - Rohd, Sinnika Birkehøj

AU - Birk, Merete

AU - Bundgaard, Anette Faurskov

AU - Laursen, Andreas Færgemand

AU - Jefsen, Oskar Hougaard

AU - Steffensen, Nanna Lawaetz

AU - Andreassen, Anna Krogh

AU - Veddum, Lotte

AU - Knudsen, Christina Bruun

AU - Enevoldsen, Mette

AU - Nymand, Marie

AU - Brandt, Julie Marie

AU - Søndergaard, Anne

AU - Carmichael, Line

AU - Gregersen, Maja

AU - Krantz, Mette Falkenberg

AU - Burton, Birgitte Klee

AU - Dietz, Martin

AU - Nudel, Ron

AU - Johnsen, Line Korsgaard

AU - Larsen, Kit Melissa

AU - Meder, David

AU - Hulme, Oliver James

AU - Baaré, William Frans Christiaan

AU - Madsen, Kathrine Skak

AU - Lund, Torben Ellegaard

AU - Østergaard, Leif

AU - Juul, Anders

AU - Kjær, Troels Wesenberg

AU - Hjorthøj, Carsten

AU - Siebner, Hartwig Roman

AU - Mors, Ole

AU - Nordentoft, Merete

N1 - Publisher Copyright: Copyright © 2022 Thorup, Hemager, Bliksted, Greve, Ohland, Wilms, Rohd, Birk, Bundgaard, Laursen, Jefsen, Steffensen, Andreassen, Veddum, Knudsen, Enevoldsen, Nymand, Brandt, Søndergaard, Carmichael, Gregersen, Krantz, Burton, Dietz, Nudel, Johnsen, Larsen, Meder, Hulme, Baaré, Madsen, Lund, Østergaard, Juul, Kjær, Hjorthøj, Siebner, Mors and Nordentoft.

PY - 2022

Y1 - 2022

N2 - Background: Children born to parents with severe mental illness have gained more attention during the last decades because of increasing evidence documenting that these children constitute a population with an increased risk of developing mental illness and other negative life outcomes. Because of high-quality research with cohorts of offspring with familial risk and increased knowledge about gene–environment interactions, early interventions and preventive strategies are now being developed all over the world. Adolescence is a period characterized by massive changes, both in terms of physical, neurologic, psychological, social, and behavioral aspects. It is also the period of life with the highest risk of experiencing onset of a mental disorder. Therefore, investigating the impact of various risk and resilience factors in adolescence is important. Methods: The Danish High-Risk and Resilience Study started data collection in 2012, where 522 7-year-old children were enrolled in the first wave of the study, the VIA 7 study. The cohort was identified through Danish registers based on diagnoses of the parents. A total of 202 children had a parent diagnosed with schizophrenia, 120 children had a parent diagnosed with bipolar disorder, and 200 children had parents without these diagnoses. At age 11 years, all children were assessed for the second time in the VIA 11 study, with a follow-up retention rate of 89%. A comprehensive assessment battery covering domains of psychopathology, neurocognition, social cognition and behavior, motor development and physical health, genetic analyses, attachment, stress, parental functioning, and home environment was carried out at each wave. Magnetic resonance imaging scans of the brain and electroencephalograms were included from age 11 years. This study protocol describes the third wave of assessment, the VIA 15 study, participants being 15 years of age and the full, 3-day-long assessment battery this time including also risk behavior, magnetoencephalography, sleep, and a white noise paradigm. Data collection started on May 1, 2021. Discussion: We will discuss the importance of longitudinal studies and cross-sectional data collection and how studies like this may inform us about unmet needs and windows of opportunity for future preventive interventions, early illness identification, and treatment in the future.

AB - Background: Children born to parents with severe mental illness have gained more attention during the last decades because of increasing evidence documenting that these children constitute a population with an increased risk of developing mental illness and other negative life outcomes. Because of high-quality research with cohorts of offspring with familial risk and increased knowledge about gene–environment interactions, early interventions and preventive strategies are now being developed all over the world. Adolescence is a period characterized by massive changes, both in terms of physical, neurologic, psychological, social, and behavioral aspects. It is also the period of life with the highest risk of experiencing onset of a mental disorder. Therefore, investigating the impact of various risk and resilience factors in adolescence is important. Methods: The Danish High-Risk and Resilience Study started data collection in 2012, where 522 7-year-old children were enrolled in the first wave of the study, the VIA 7 study. The cohort was identified through Danish registers based on diagnoses of the parents. A total of 202 children had a parent diagnosed with schizophrenia, 120 children had a parent diagnosed with bipolar disorder, and 200 children had parents without these diagnoses. At age 11 years, all children were assessed for the second time in the VIA 11 study, with a follow-up retention rate of 89%. A comprehensive assessment battery covering domains of psychopathology, neurocognition, social cognition and behavior, motor development and physical health, genetic analyses, attachment, stress, parental functioning, and home environment was carried out at each wave. Magnetic resonance imaging scans of the brain and electroencephalograms were included from age 11 years. This study protocol describes the third wave of assessment, the VIA 15 study, participants being 15 years of age and the full, 3-day-long assessment battery this time including also risk behavior, magnetoencephalography, sleep, and a white noise paradigm. Data collection started on May 1, 2021. Discussion: We will discuss the importance of longitudinal studies and cross-sectional data collection and how studies like this may inform us about unmet needs and windows of opportunity for future preventive interventions, early illness identification, and treatment in the future.

KW - adolescent mental health

KW - bipolar disorder

KW - developmental trajectories

KW - familial high risk

KW - schizophrenia

U2 - 10.3389/fpsyt.2022.809807

DO - 10.3389/fpsyt.2022.809807

M3 - Journal article

C2 - 35444571

AN - SCOPUS:85128604359

VL - 13

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

SN - 1664-0640

M1 - 809807

ER -