The effect of physical exercise on cerebral blood flow in Alzheimer's disease
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
The effect of physical exercise on cerebral blood flow in Alzheimer's disease. / van der Kleij, Lisa A; Petersen, Esben T; Siebner, Hartwig R; Hendrikse, Jeroen; Frederiksen, Kristian S; Sobol, Nanna A; Hasselbalch, Steen G; Garde, Ellen.
In: NeuroImage: Clinical, Vol. 20, 2018, p. 650-654.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The effect of physical exercise on cerebral blood flow in Alzheimer's disease
AU - van der Kleij, Lisa A
AU - Petersen, Esben T
AU - Siebner, Hartwig R
AU - Hendrikse, Jeroen
AU - Frederiksen, Kristian S
AU - Sobol, Nanna A
AU - Hasselbalch, Steen G
AU - Garde, Ellen
PY - 2018
Y1 - 2018
N2 - In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.
AB - In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.
KW - Aged
KW - Alzheimer Disease/diagnosis
KW - Brief Psychiatric Rating Scale
KW - Cerebrovascular Circulation/physiology
KW - Exercise/physiology
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Single-Blind Method
U2 - 10.1016/j.nicl.2018.09.003
DO - 10.1016/j.nicl.2018.09.003
M3 - Journal article
C2 - 30211001
VL - 20
SP - 650
EP - 654
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
SN - 2213-1582
ER -
ID: 216506461