The right posterior inferior frontal gyrus contributes to phonological word decisions in the healthy brain: evidence from dual-site TMS
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The right posterior inferior frontal gyrus contributes to phonological word decisions in the healthy brain : evidence from dual-site TMS. / Hartwigsen, Gesa; Price, Cathy J; Baumgaertner, Annette; Geiss, Gesine; Koehnke, Maria; Ulmer, Stephan; Siebner, Hartwig R.
In: Neuropsychologia, Vol. 48, No. 10, 01.08.2010, p. 3155-63.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The right posterior inferior frontal gyrus contributes to phonological word decisions in the healthy brain
T2 - evidence from dual-site TMS
AU - Hartwigsen, Gesa
AU - Price, Cathy J
AU - Baumgaertner, Annette
AU - Geiss, Gesine
AU - Koehnke, Maria
AU - Ulmer, Stephan
AU - Siebner, Hartwig R
N1 - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
PY - 2010/8/1
Y1 - 2010/8/1
N2 - There is consensus that the left hemisphere plays a dominant role in language processing, but functional imaging studies have shown that the right as well as the left posterior inferior frontal gyri (pIFG) are activated when healthy right-handed individuals make phonological word decisions. Here we used online transcranial magnetic stimulation (TMS) to examine the functional relevance of the right pIFG for auditory and visual phonological decisions. Healthy right-handed individuals made phonological or semantic word judgements on the same set of auditorily and visually presented words while they received stereotactically guided TMS over the left, right or bilateral pIFG (n=14) or the anterior left, right or bilateral IFG (n=14). TMS started 100ms after word onset and consisted of four stimuli given at a rate of 10Hz and intensity of 90% of active motor threshold. Compared to TMS of aIFG, TMS of pIFG impaired reaction times and accuracy of phonological but not semantic decisions for visually and auditorily presented words. TMS over left, right or bilateral pIFG disrupted phonological processing to a similar degree. In a follow-up experiment, the intensity threshold for delaying phonological judgements was identical for unilateral TMS of left and right pIFG. These findings indicate that an intact function of right pIFG is necessary for accurate and efficient phonological decisions in the healthy brain with no evidence that the left and right pIFG can compensate for one another during online TMS. Our findings motivate detailed studies of phonological processing in patients with acute and chronic damage of the right pIFG.
AB - There is consensus that the left hemisphere plays a dominant role in language processing, but functional imaging studies have shown that the right as well as the left posterior inferior frontal gyri (pIFG) are activated when healthy right-handed individuals make phonological word decisions. Here we used online transcranial magnetic stimulation (TMS) to examine the functional relevance of the right pIFG for auditory and visual phonological decisions. Healthy right-handed individuals made phonological or semantic word judgements on the same set of auditorily and visually presented words while they received stereotactically guided TMS over the left, right or bilateral pIFG (n=14) or the anterior left, right or bilateral IFG (n=14). TMS started 100ms after word onset and consisted of four stimuli given at a rate of 10Hz and intensity of 90% of active motor threshold. Compared to TMS of aIFG, TMS of pIFG impaired reaction times and accuracy of phonological but not semantic decisions for visually and auditorily presented words. TMS over left, right or bilateral pIFG disrupted phonological processing to a similar degree. In a follow-up experiment, the intensity threshold for delaying phonological judgements was identical for unilateral TMS of left and right pIFG. These findings indicate that an intact function of right pIFG is necessary for accurate and efficient phonological decisions in the healthy brain with no evidence that the left and right pIFG can compensate for one another during online TMS. Our findings motivate detailed studies of phonological processing in patients with acute and chronic damage of the right pIFG.
KW - Acoustic Stimulation
KW - Adult
KW - Analysis of Variance
KW - Brain Mapping
KW - Decision Making
KW - Electric Stimulation
KW - Female
KW - Follow-Up Studies
KW - Frontal Lobe
KW - Functional Laterality
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Magnetic Resonance Imaging
KW - Male
KW - Neuropsychological Tests
KW - Oxygen
KW - Phonetics
KW - Photic Stimulation
KW - Reaction Time
KW - Transcranial Magnetic Stimulation
KW - Vocabulary
KW - Young Adult
U2 - 10.1016/j.neuropsychologia.2010.06.032
DO - 10.1016/j.neuropsychologia.2010.06.032
M3 - Journal article
C2 - 20600177
VL - 48
SP - 3155
EP - 3163
JO - Neuropsychologia
JF - Neuropsychologia
SN - 0028-3932
IS - 10
ER -
ID: 33437988