Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults
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Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults. / Chu, Congying; Holst, Sebastian C.; Elmenhorst, Eva Maria; Foerges, Anna L.; Li, Changhong; Lange, Denise; Hennecke, Eva; Baur, Diego M.; Beer, Simone; Hoffstaedter, Felix; Knudsen, Gitte M.; Aeschbach, Daniel; Bauer, Andreas; Landolt, Hans-Peter; Elmenhorst, David.
In: Journal of Neuroscience, Vol. 43, No. 12, 2023, p. 2168-2177.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults
AU - Chu, Congying
AU - Holst, Sebastian C.
AU - Elmenhorst, Eva Maria
AU - Foerges, Anna L.
AU - Li, Changhong
AU - Lange, Denise
AU - Hennecke, Eva
AU - Baur, Diego M.
AU - Beer, Simone
AU - Hoffstaedter, Felix
AU - Knudsen, Gitte M.
AU - Aeschbach, Daniel
AU - Bauer, Andreas
AU - Landolt, Hans-Peter
AU - Elmenhorst, David
N1 - Publisher Copyright: Copyright © 2023 the authors.
PY - 2023
Y1 - 2023
N2 - Sleep loss pervasively affects the human brain at multiple levels. Age-related changes in several sleep characteristics indicate that reduced sleep quality is a frequent characteristic of aging. Conversely, sleep disruption may accelerate the aging process, yet it is not known what will happen to the age status of the brain if we can manipulate sleep conditions. To tackle this question, we used an approach of brain age to investigate whether sleep loss would cause age-related changes in the brain. We included MRI data of 134 healthy volunteers (mean chronological age of 25.3 between the age of 19 and 39 years, 42 females/92 males) from five datasets with different sleep conditions. Across three datasets with the condition of total sleep deprivation (.24 h of prolonged wakefulness), we consistently observed that total sleep deprivation increased brain age by 1–2 years regarding the group mean difference with the baseline. Interestingly, after one night of recovery sleep, brain age was not different from baseline. We also demonstrated the associations between the change in brain age after total sleep deprivation and the sleep variables measured during the recovery night. By contrast, brain age was not significantly changed by either acute (3 h time-in-bed for one night) or chronic partial sleep restriction (5 h time-in-bed for five continuous nights). Together, the convergent findings indicate that acute total sleep loss changes brain morphology in an aging-like direction in young participants and that these changes are reversible by recovery sleep.
AB - Sleep loss pervasively affects the human brain at multiple levels. Age-related changes in several sleep characteristics indicate that reduced sleep quality is a frequent characteristic of aging. Conversely, sleep disruption may accelerate the aging process, yet it is not known what will happen to the age status of the brain if we can manipulate sleep conditions. To tackle this question, we used an approach of brain age to investigate whether sleep loss would cause age-related changes in the brain. We included MRI data of 134 healthy volunteers (mean chronological age of 25.3 between the age of 19 and 39 years, 42 females/92 males) from five datasets with different sleep conditions. Across three datasets with the condition of total sleep deprivation (.24 h of prolonged wakefulness), we consistently observed that total sleep deprivation increased brain age by 1–2 years regarding the group mean difference with the baseline. Interestingly, after one night of recovery sleep, brain age was not different from baseline. We also demonstrated the associations between the change in brain age after total sleep deprivation and the sleep variables measured during the recovery night. By contrast, brain age was not significantly changed by either acute (3 h time-in-bed for one night) or chronic partial sleep restriction (5 h time-in-bed for five continuous nights). Together, the convergent findings indicate that acute total sleep loss changes brain morphology in an aging-like direction in young participants and that these changes are reversible by recovery sleep.
KW - brain age
KW - sleep deprivation
KW - T1 MRI
U2 - 10.1523/JNEUROSCI.0790-22.2023
DO - 10.1523/JNEUROSCI.0790-22.2023
M3 - Journal article
C2 - 36804738
AN - SCOPUS:85151042897
VL - 43
SP - 2168
EP - 2177
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
SN - 0270-6474
IS - 12
ER -
ID: 362750103