Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study
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Trait Openness and serotonin 2A receptors in healthy volunteers : A positron emission tomography study. / Stenbaek, Dea Siggaard; Kristiansen, Sara; Burmester, Daniel; Madsen, Martin Korsbak; Frokjaer, Vibe Gedsoe; Knudsen, Gitte Moos; Fisher, Patrick MacDonald.
In: Human Brain Mapping, Vol. 40, No. 7, 05.2019, p. 2117-2124.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Trait Openness and serotonin 2A receptors in healthy volunteers
T2 - A positron emission tomography study
AU - Stenbaek, Dea Siggaard
AU - Kristiansen, Sara
AU - Burmester, Daniel
AU - Madsen, Martin Korsbak
AU - Frokjaer, Vibe Gedsoe
AU - Knudsen, Gitte Moos
AU - Fisher, Patrick MacDonald
N1 - © 2019 Wiley Periodicals, Inc.
PY - 2019/5
Y1 - 2019/5
N2 - Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5-HT2A R) agonist psilocybin. However, no studies have investigated whether 5-HT2A R availability as imaged using positron emission tomography (PET) is associated with this trait. In 159 healthy individuals (53 females), the association between 5-HT2A R binding in neocortex imaged with [18 F]altanserin or [11 C]Cimbi-36 PET and personality trait Openness was investigated using linear regression models. In these models the influence of sex on the association was also investigated. Trait Openness was assessed with the NEO Personality Inventory-Revised. No significant associations between neocortical 5-HT2A R binding and trait Openness were found for [18 F]altanserin (p = 0.5) or [11 C]Cimbi-36 (p = 0.8). Pooling the data in a combined model did not substantially change our results (p = 0.4). No significant interactions with sex were found (p > 0.35). Our results indicate that differences in 5-HT2A R availability are not related to variations in trait Openness in healthy individuals. Although stimulation of the 5-HT2A R with compounds such as psilocybin may contribute to long-term changes in trait Openness, there is no evidence in favor of an association between 5-HT2A R and trait Openness.
AB - Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5-HT2A R) agonist psilocybin. However, no studies have investigated whether 5-HT2A R availability as imaged using positron emission tomography (PET) is associated with this trait. In 159 healthy individuals (53 females), the association between 5-HT2A R binding in neocortex imaged with [18 F]altanserin or [11 C]Cimbi-36 PET and personality trait Openness was investigated using linear regression models. In these models the influence of sex on the association was also investigated. Trait Openness was assessed with the NEO Personality Inventory-Revised. No significant associations between neocortical 5-HT2A R binding and trait Openness were found for [18 F]altanserin (p = 0.5) or [11 C]Cimbi-36 (p = 0.8). Pooling the data in a combined model did not substantially change our results (p = 0.4). No significant interactions with sex were found (p > 0.35). Our results indicate that differences in 5-HT2A R availability are not related to variations in trait Openness in healthy individuals. Although stimulation of the 5-HT2A R with compounds such as psilocybin may contribute to long-term changes in trait Openness, there is no evidence in favor of an association between 5-HT2A R and trait Openness.
U2 - 10.1002/hbm.24511
DO - 10.1002/hbm.24511
M3 - Journal article
C2 - 30633430
VL - 40
SP - 2117
EP - 2124
JO - Human Brain Mapping
JF - Human Brain Mapping
SN - 1065-9471
IS - 7
ER -
ID: 234703328