Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis

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Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis. / Danielsen, Karen Vagner; Hove, Jens Dahlgaard; Nabilou, Puria; Yin, Meng; Chen, Jun; Zhao, Mirabella; Kallemose, Thomas; Teisner, Ane Sogaard; Siebner, Hartwig Roman; Ehman, Richard L.; Møller, Soren; Bendtsen, Flemming.

In: Liver International, Vol. 41, No. 9, 2021, p. 2149-2158.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Danielsen, KV, Hove, JD, Nabilou, P, Yin, M, Chen, J, Zhao, M, Kallemose, T, Teisner, AS, Siebner, HR, Ehman, RL, Møller, S & Bendtsen, F 2021, 'Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis', Liver International, vol. 41, no. 9, pp. 2149-2158. https://doi.org/10.1111/liv.14981

APA

Danielsen, K. V., Hove, J. D., Nabilou, P., Yin, M., Chen, J., Zhao, M., Kallemose, T., Teisner, A. S., Siebner, H. R., Ehman, R. L., Møller, S., & Bendtsen, F. (2021). Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis. Liver International, 41(9), 2149-2158. https://doi.org/10.1111/liv.14981

Vancouver

Danielsen KV, Hove JD, Nabilou P, Yin M, Chen J, Zhao M et al. Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis. Liver International. 2021;41(9):2149-2158. https://doi.org/10.1111/liv.14981

Author

Danielsen, Karen Vagner ; Hove, Jens Dahlgaard ; Nabilou, Puria ; Yin, Meng ; Chen, Jun ; Zhao, Mirabella ; Kallemose, Thomas ; Teisner, Ane Sogaard ; Siebner, Hartwig Roman ; Ehman, Richard L. ; Møller, Soren ; Bendtsen, Flemming. / Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis. In: Liver International. 2021 ; Vol. 41, No. 9. pp. 2149-2158.

Bibtex

@article{54a53c0307934a6f8edf4eef63b7b596,
title = "Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis",
abstract = "BackgroundMR elastography can determine organ-related stiffness, which reflects the degree of fibrosis. Liver stiffness increases in cirrhosis, and stiffness increases further post-prandially due to increased portal blood in-flow. Non-selective beta-blockers (NSBB) reduce the portal venous inflow, but their effect on liver and spleen stiffness are disputed.AimsTo assess whether MR elastography of the liver or spleen reflects the severity of cirrhosis, whether treatment with NSBB changes liver and spleen stiffness and whether changes in stiffness can predict the effect of NSBB on portal pressure.MethodsFifty-two patients with cirrhosis underwent liver vein catheterization and two-dimensional (2D) MR elastography on separate days. Thirty-six of the patients had a hepatic venous pressure gradient (HVPG) of ≥12 mmHg and were tested prior to, and after, intravenous infusion of NSBB using HVPG measurement and MR elastography.ResultsHVPG showed a strong, positive, linear relationship with liver stiffness (r2 = 0.92; P < .001) and spleen stiffness (r2 = 0.94; P < .001). The cut-off points for identifying patients with a HVPG ≥ 12 mmHg were 7.7 kPa for liver stiffness (sensitivity 0.78, specificity 0.64) and 10.5 kPa for spleen stiffness (sensitivity 0.8, specificity 0.79).Intravenous administration of NSBB significantly decreased spleen stiffness by 6.9% (CI: 3.5-10.4, P < .001), but NSBB had no consistent effect on liver stiffness. However, changes in spleen stiffness were not related to the HVPG response (P = .75).ConclusionsTwo-dimensional MR elastographic estimation of liver or spleen stiffness reflects the degree of portal hypertension in patients with liver cirrhosis, but changes in stiffness after NSBB do not predict the effect on HVPG.",
keywords = "beta-blockers, imaging, liver cirrhosis, magnetic resonance elastography, portal hypertension",
author = "Danielsen, {Karen Vagner} and Hove, {Jens Dahlgaard} and Puria Nabilou and Meng Yin and Jun Chen and Mirabella Zhao and Thomas Kallemose and Teisner, {Ane Sogaard} and Siebner, {Hartwig Roman} and Ehman, {Richard L.} and Soren M{\o}ller and Flemming Bendtsen",
year = "2021",
doi = "10.1111/liv.14981",
language = "English",
volume = "41",
pages = "2149--2158",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis

AU - Danielsen, Karen Vagner

AU - Hove, Jens Dahlgaard

AU - Nabilou, Puria

AU - Yin, Meng

AU - Chen, Jun

AU - Zhao, Mirabella

AU - Kallemose, Thomas

AU - Teisner, Ane Sogaard

AU - Siebner, Hartwig Roman

AU - Ehman, Richard L.

AU - Møller, Soren

AU - Bendtsen, Flemming

PY - 2021

Y1 - 2021

N2 - BackgroundMR elastography can determine organ-related stiffness, which reflects the degree of fibrosis. Liver stiffness increases in cirrhosis, and stiffness increases further post-prandially due to increased portal blood in-flow. Non-selective beta-blockers (NSBB) reduce the portal venous inflow, but their effect on liver and spleen stiffness are disputed.AimsTo assess whether MR elastography of the liver or spleen reflects the severity of cirrhosis, whether treatment with NSBB changes liver and spleen stiffness and whether changes in stiffness can predict the effect of NSBB on portal pressure.MethodsFifty-two patients with cirrhosis underwent liver vein catheterization and two-dimensional (2D) MR elastography on separate days. Thirty-six of the patients had a hepatic venous pressure gradient (HVPG) of ≥12 mmHg and were tested prior to, and after, intravenous infusion of NSBB using HVPG measurement and MR elastography.ResultsHVPG showed a strong, positive, linear relationship with liver stiffness (r2 = 0.92; P < .001) and spleen stiffness (r2 = 0.94; P < .001). The cut-off points for identifying patients with a HVPG ≥ 12 mmHg were 7.7 kPa for liver stiffness (sensitivity 0.78, specificity 0.64) and 10.5 kPa for spleen stiffness (sensitivity 0.8, specificity 0.79).Intravenous administration of NSBB significantly decreased spleen stiffness by 6.9% (CI: 3.5-10.4, P < .001), but NSBB had no consistent effect on liver stiffness. However, changes in spleen stiffness were not related to the HVPG response (P = .75).ConclusionsTwo-dimensional MR elastographic estimation of liver or spleen stiffness reflects the degree of portal hypertension in patients with liver cirrhosis, but changes in stiffness after NSBB do not predict the effect on HVPG.

AB - BackgroundMR elastography can determine organ-related stiffness, which reflects the degree of fibrosis. Liver stiffness increases in cirrhosis, and stiffness increases further post-prandially due to increased portal blood in-flow. Non-selective beta-blockers (NSBB) reduce the portal venous inflow, but their effect on liver and spleen stiffness are disputed.AimsTo assess whether MR elastography of the liver or spleen reflects the severity of cirrhosis, whether treatment with NSBB changes liver and spleen stiffness and whether changes in stiffness can predict the effect of NSBB on portal pressure.MethodsFifty-two patients with cirrhosis underwent liver vein catheterization and two-dimensional (2D) MR elastography on separate days. Thirty-six of the patients had a hepatic venous pressure gradient (HVPG) of ≥12 mmHg and were tested prior to, and after, intravenous infusion of NSBB using HVPG measurement and MR elastography.ResultsHVPG showed a strong, positive, linear relationship with liver stiffness (r2 = 0.92; P < .001) and spleen stiffness (r2 = 0.94; P < .001). The cut-off points for identifying patients with a HVPG ≥ 12 mmHg were 7.7 kPa for liver stiffness (sensitivity 0.78, specificity 0.64) and 10.5 kPa for spleen stiffness (sensitivity 0.8, specificity 0.79).Intravenous administration of NSBB significantly decreased spleen stiffness by 6.9% (CI: 3.5-10.4, P < .001), but NSBB had no consistent effect on liver stiffness. However, changes in spleen stiffness were not related to the HVPG response (P = .75).ConclusionsTwo-dimensional MR elastographic estimation of liver or spleen stiffness reflects the degree of portal hypertension in patients with liver cirrhosis, but changes in stiffness after NSBB do not predict the effect on HVPG.

KW - beta-blockers

KW - imaging

KW - liver cirrhosis

KW - magnetic resonance elastography

KW - portal hypertension

U2 - 10.1111/liv.14981

DO - 10.1111/liv.14981

M3 - Journal article

C2 - 34060714

VL - 41

SP - 2149

EP - 2158

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 9

ER -

ID: 273068054