Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

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  • Christian Mirian
  • Tareq A Juratli
  • Felix Sahm
  • Sabine Spiegl-Kreinecker
  • Matthieu Peyre
  • Annamaria Biczok
  • Joerg Christian Tonn
  • Stéphane Goutagny
  • Luca Bertero
  • Andrea Daniela Maier
  • Lasse Rehné Jensen
  • Gabriele Schackert
  • Helle Broholm
  • Daniel P Cahill
  • Priscilla K Brastianos
  • Morten Ziebell
TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas
Original languageEnglish
Article numbere12773
JournalNeuropathology and Applied Neurobiology
Issue number3
Number of pages5
Publication statusPublished - 2022

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