Angiogenic factors and the lectin pathway of complement in women with secondary recurrent pregnancy loss
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Angiogenic factors and the lectin pathway of complement in women with secondary recurrent pregnancy loss. / Krog, M. C.; Flachs, E. M.; Kolte, A. M.; de Jager, W.; Meyaard, L.; Christiansen, O. B.; Steffensen, R.; Vomstein, K.; Garred, P.; Nielsen, H. S.
In: Journal of Reproductive Immunology, Vol. 163, 104221, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Angiogenic factors and the lectin pathway of complement in women with secondary recurrent pregnancy loss
AU - Krog, M. C.
AU - Flachs, E. M.
AU - Kolte, A. M.
AU - de Jager, W.
AU - Meyaard, L.
AU - Christiansen, O. B.
AU - Steffensen, R.
AU - Vomstein, K.
AU - Garred, P.
AU - Nielsen, H. S.
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - The poor remodeling of placental spiral arteries seen in preeclampsia is also discussed to contribute to recurrent pregnancy loss (RPL) preceded by abnormal angiogenesis and excessive complement activation. Low levels of Mannose-binding-lectin (MBL), a pattern recognition molecule (PRM) of the lectin pathway, have been found in women with RPL. We propose that pregnancy loss is connected to defective angiogenesis with reperfusion damage in the placenta and decreased levels of PRM in the lectin pathway in women with RPL. In this cohort study, we investigate the angiogenic factors and the lectin complement pathway in early pregnancy and their time-dependent relationship with pregnancy outcomes in 76 women with secondary RPL (sRPL) who have at least four prior pregnancy losses and a live birth. We evaluated levels of Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), Vascular Endothelial Growth Factor (VEGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and the PRMs, MBL, ficolin-1, −2, −3 and an additional soluble PRM, Pentraxin-3, during the 5th, 6th, and 7th gestational weeks. Our results showed that, compared to live births, pregnancies that ended in loss were associated with elevated VEGF levels and decreased levels of the Ang-2/Ang-1 ratio. Also, increasing levels of ficolin-2 were significantly associated with pregnancy loss, with MBL showing no association. Our research suggests that women with sRPL may have inadequate placentation with impaired angiogenesis in pregnancies ending in a loss.
AB - The poor remodeling of placental spiral arteries seen in preeclampsia is also discussed to contribute to recurrent pregnancy loss (RPL) preceded by abnormal angiogenesis and excessive complement activation. Low levels of Mannose-binding-lectin (MBL), a pattern recognition molecule (PRM) of the lectin pathway, have been found in women with RPL. We propose that pregnancy loss is connected to defective angiogenesis with reperfusion damage in the placenta and decreased levels of PRM in the lectin pathway in women with RPL. In this cohort study, we investigate the angiogenic factors and the lectin complement pathway in early pregnancy and their time-dependent relationship with pregnancy outcomes in 76 women with secondary RPL (sRPL) who have at least four prior pregnancy losses and a live birth. We evaluated levels of Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), Vascular Endothelial Growth Factor (VEGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and the PRMs, MBL, ficolin-1, −2, −3 and an additional soluble PRM, Pentraxin-3, during the 5th, 6th, and 7th gestational weeks. Our results showed that, compared to live births, pregnancies that ended in loss were associated with elevated VEGF levels and decreased levels of the Ang-2/Ang-1 ratio. Also, increasing levels of ficolin-2 were significantly associated with pregnancy loss, with MBL showing no association. Our research suggests that women with sRPL may have inadequate placentation with impaired angiogenesis in pregnancies ending in a loss.
KW - Angiogenesis
KW - Complement system
KW - Poor placentation
KW - Recurrent pregnancy loss
KW - The lectin pathway
U2 - 10.1016/j.jri.2024.104221
DO - 10.1016/j.jri.2024.104221
M3 - Journal article
C2 - 38447288
AN - SCOPUS:85186690269
VL - 163
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
SN - 0165-0378
M1 - 104221
ER -
ID: 385587573