Chance of live birth in the first pregnancy after referral among patients with recurrent pregnancy loss is not influenced by their relatives’ reproductive history
Research output: Contribution to journal › Journal article › Research › peer-review
Purpose: Recurrent pregnancy loss (RPL) is defined as three or more consecutive pregnancy losses and affects 1–3% of couples trying to conceive. Pregnancy loss is more common among RPL patients’ siblings than in the general population. Our objective was to investigate whether first-degree relatives with pregnancy losses influenced the chance of live birth in the first pregnancy after referral among women with RPL. Materials and methods: This is a cohort study of 2138 women with RPL seen at the Danish RPL Unit at Copenhagen University Hospital, Rigshospitalet between January 1st 2000 and December 31st 2017 with follow-up until December 2018. Pregnancies among first-degree relatives were reported by patients at their first consultation. Chance of live birth after referral was compared by logistic regression analysis. Results: Overall, 76% of the referred women achieved a pregnancy after referral and of these, 58% delivered a live born child. Women whose mother had experienced pregnancy loss were referred at a younger age than women with no pregnancy losses among first-degree relatives (mean age 33.6 (SD 4.6) versus 34.3 (SD 4.5), p = 0.002). Pregnancy losses among first-degree relatives did not influence chance of live birth. Conclusions: Our results indicate that pregnancy losses among first-degree family members is not an important risk factor for outcome of the first pregnancy after referral among women with RPL.
Original language | English |
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Journal | European Journal of Contraception and Reproductive Health Care |
Volume | 25 |
Issue number | 3 |
Pages (from-to) | 209-212 |
Number of pages | 4 |
ISSN | 1362-5187 |
DOIs | |
Publication status | Published - 2020 |
- cohort study, family history, Recurrent pregnancy loss
Research areas
ID: 251581390