Bidirectional 5-year risks of diabetic retinopathy, glaucoma and/or ocular hypertension: Results from a national screening programme
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Bidirectional 5-year risks of diabetic retinopathy, glaucoma and/or ocular hypertension : Results from a national screening programme. / Sperling, Signe; Stokholm, Lonny; Thykjær, Anne Suhr; Pedersen, Frederik Nørregaard; Möller, Sören; Laugesen, Caroline Schmidt; Andersen, Nis; Andresen, Jens; Bek, Toke; la Cour, Morten; Hajari, Javad; Heegaard, Steffen; Højlund, Kurt; Kawasaki, Ryo; Kolko, Miriam; Schielke, Katja Christina; Rubin, Katrine Hass; Vestergaard, Anders Højslet; Grauslund, Jakob.
In: Acta Ophthalmologica, Vol. 101, No. 4, 2023, p. 384-391.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Bidirectional 5-year risks of diabetic retinopathy, glaucoma and/or ocular hypertension
T2 - Results from a national screening programme
AU - Sperling, Signe
AU - Stokholm, Lonny
AU - Thykjær, Anne Suhr
AU - Pedersen, Frederik Nørregaard
AU - Möller, Sören
AU - Laugesen, Caroline Schmidt
AU - Andersen, Nis
AU - Andresen, Jens
AU - Bek, Toke
AU - la Cour, Morten
AU - Hajari, Javad
AU - Heegaard, Steffen
AU - Højlund, Kurt
AU - Kawasaki, Ryo
AU - Kolko, Miriam
AU - Schielke, Katja Christina
AU - Rubin, Katrine Hass
AU - Vestergaard, Anders Højslet
AU - Grauslund, Jakob
N1 - Publisher Copyright: © 2022 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.
PY - 2023
Y1 - 2023
N2 - Purpose: We aimed to investigate if diabetic retinopathy (DR), glaucoma and/or ocular hypertension (OHT) are prospectively linked, as previous studies have proposed cross-sectional associations, but longitudinal data from larger cohorts are lacking. Methods: We performed a bidirectional 5 years prospective, registry-based cohort study. We extracted data from national registers, including the Danish Registry of Diabetic Retinopathy, the Danish Civil Registration System, the Danish National Patient Register and the Danish National Prescription Registry. DR level was defined by the highest level of the two eyes. Glaucoma and/or OHT was defined by diagnostic codes (H40*) or at least three redeemed prescriptions of glaucoma medication (S01E*) within 1 year. We included 205 970 persons with diabetes and 1 003 170 age- and gender-matched non-diabetes controls. Exposures were level-specific DR (i) and glaucoma and/or OHT (ii), and outcomes were hazard ratios (HRs) for 5 years incident glaucoma and/or OHT (i) and DR (ii). Results: Persons with diabetes were more likely to develop glaucoma and/or OHT (multivariable adjusted HR 1.11, 95% CI 1.06–1.15), but this did not depend on the level of DR. In persons with diabetes, those with glaucoma and/or OHT were more likely to develop DR (multivariable adjusted HR 1.12, 95% CI 1.03–1.23) within 5 years. Conclusion: In a national cohort, diabetes associated with a little higher risk of upcoming glaucoma and/or OHT, and, inversely, the presence of the latter predicted a higher risk of incident DR. Nevertheless, our data do not seem to justify including glaucoma evaluation in the national Danish DR-screening programme.
AB - Purpose: We aimed to investigate if diabetic retinopathy (DR), glaucoma and/or ocular hypertension (OHT) are prospectively linked, as previous studies have proposed cross-sectional associations, but longitudinal data from larger cohorts are lacking. Methods: We performed a bidirectional 5 years prospective, registry-based cohort study. We extracted data from national registers, including the Danish Registry of Diabetic Retinopathy, the Danish Civil Registration System, the Danish National Patient Register and the Danish National Prescription Registry. DR level was defined by the highest level of the two eyes. Glaucoma and/or OHT was defined by diagnostic codes (H40*) or at least three redeemed prescriptions of glaucoma medication (S01E*) within 1 year. We included 205 970 persons with diabetes and 1 003 170 age- and gender-matched non-diabetes controls. Exposures were level-specific DR (i) and glaucoma and/or OHT (ii), and outcomes were hazard ratios (HRs) for 5 years incident glaucoma and/or OHT (i) and DR (ii). Results: Persons with diabetes were more likely to develop glaucoma and/or OHT (multivariable adjusted HR 1.11, 95% CI 1.06–1.15), but this did not depend on the level of DR. In persons with diabetes, those with glaucoma and/or OHT were more likely to develop DR (multivariable adjusted HR 1.12, 95% CI 1.03–1.23) within 5 years. Conclusion: In a national cohort, diabetes associated with a little higher risk of upcoming glaucoma and/or OHT, and, inversely, the presence of the latter predicted a higher risk of incident DR. Nevertheless, our data do not seem to justify including glaucoma evaluation in the national Danish DR-screening programme.
KW - diabetes
KW - diabetic retinopathy
KW - epidemiology
KW - glaucoma
KW - ocular hypertension
U2 - 10.1111/aos.15300
DO - 10.1111/aos.15300
M3 - Journal article
C2 - 36514165
AN - SCOPUS:85144128949
VL - 101
SP - 384
EP - 391
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 4
ER -
ID: 330781887