Controversial preservation of eye drops: The toxicity of benzalkonium chloride

Research output: Contribution to journal › Review › Research › peer-review

Standard

Controversial preservation of eye drops : The toxicity of benzalkonium chloride. / Hedengran, Anne; Kolko, Miriam.

In: Adverse Drug Reaction Bulletin, Vol. 338, No. 1, 2023, p. 1311-1314.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hedengran, A & Kolko, M 2023, 'Controversial preservation of eye drops: The toxicity of benzalkonium chloride', Adverse Drug Reaction Bulletin, vol. 338, no. 1, pp. 1311-1314. https://doi.org/10.1097/FAD.0000000000000066

APA

Hedengran, A., & Kolko, M. (2023). Controversial preservation of eye drops: The toxicity of benzalkonium chloride. Adverse Drug Reaction Bulletin, 338(1), 1311-1314. https://doi.org/10.1097/FAD.0000000000000066

Vancouver

Hedengran A, Kolko M. Controversial preservation of eye drops: The toxicity of benzalkonium chloride. Adverse Drug Reaction Bulletin. 2023;338(1):1311-1314. https://doi.org/10.1097/FAD.0000000000000066

Author

Hedengran, Anne ; Kolko, Miriam. / Controversial preservation of eye drops : The toxicity of benzalkonium chloride. In: Adverse Drug Reaction Bulletin. 2023 ; Vol. 338, No. 1. pp. 1311-1314.

Bibtex

@article{0d34dcef83204bc4a75fa1e4cabf3b2d,
title = "Controversial preservation of eye drops: The toxicity of benzalkonium chloride",
abstract = "Eye drops are a major cornerstone in the treatment of ophthalmic diseases, and adherence is crucial. Most eye drops are preserved with the surfactant benzalkonium chloride (BAK). Great controversy revolves around the use of BAK, as BAK has continuously been proven to be cytotoxic. In cell cultures, BAK-preserved eye drops cause increased cell death, and in patients, preservation with BAK causes more side effects and ocular surface damage. Side effects can negatively affect adherence and, with this, disease control. This is namely a problem in glaucoma patients. Glaucoma is irreversible, and a lack of disease control may lead to incurable blindness. The purposes of treating ophthalmic diseases are to secure good visual acuity, ocular comfort, and good quality of life for the patients. When administering, BAK-preserved eye drops ocular damage may be inflicted and these purposes are put at risk. Preservative-free and alternatively preserved eye drops are available, why there is no need for the use of BAK.",
author = "Anne Hedengran and Miriam Kolko",
note = "Funding Information: M.K. has received funding from Laboratoires Th{\'e}a (France) for other studies. No competing interests in relation to this paper. No funding was received for the development of the current paper. ",
year = "2023",
doi = "10.1097/FAD.0000000000000066",
language = "English",
volume = "338",
pages = "1311--1314",
journal = "Adverse Drug Reaction Bulletin",
issn = "0044-6394",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Controversial preservation of eye drops

T2 - The toxicity of benzalkonium chloride

AU - Hedengran, Anne

AU - Kolko, Miriam

N1 - Funding Information: M.K. has received funding from Laboratoires Théa (France) for other studies. No competing interests in relation to this paper. No funding was received for the development of the current paper.

PY - 2023

Y1 - 2023

N2 - Eye drops are a major cornerstone in the treatment of ophthalmic diseases, and adherence is crucial. Most eye drops are preserved with the surfactant benzalkonium chloride (BAK). Great controversy revolves around the use of BAK, as BAK has continuously been proven to be cytotoxic. In cell cultures, BAK-preserved eye drops cause increased cell death, and in patients, preservation with BAK causes more side effects and ocular surface damage. Side effects can negatively affect adherence and, with this, disease control. This is namely a problem in glaucoma patients. Glaucoma is irreversible, and a lack of disease control may lead to incurable blindness. The purposes of treating ophthalmic diseases are to secure good visual acuity, ocular comfort, and good quality of life for the patients. When administering, BAK-preserved eye drops ocular damage may be inflicted and these purposes are put at risk. Preservative-free and alternatively preserved eye drops are available, why there is no need for the use of BAK.

AB - Eye drops are a major cornerstone in the treatment of ophthalmic diseases, and adherence is crucial. Most eye drops are preserved with the surfactant benzalkonium chloride (BAK). Great controversy revolves around the use of BAK, as BAK has continuously been proven to be cytotoxic. In cell cultures, BAK-preserved eye drops cause increased cell death, and in patients, preservation with BAK causes more side effects and ocular surface damage. Side effects can negatively affect adherence and, with this, disease control. This is namely a problem in glaucoma patients. Glaucoma is irreversible, and a lack of disease control may lead to incurable blindness. The purposes of treating ophthalmic diseases are to secure good visual acuity, ocular comfort, and good quality of life for the patients. When administering, BAK-preserved eye drops ocular damage may be inflicted and these purposes are put at risk. Preservative-free and alternatively preserved eye drops are available, why there is no need for the use of BAK.

U2 - 10.1097/FAD.0000000000000066

DO - 10.1097/FAD.0000000000000066

M3 - Review

AN - SCOPUS:85147307816

VL - 338

SP - 1311

EP - 1314

JO - Adverse Drug Reaction Bulletin

JF - Adverse Drug Reaction Bulletin

SN - 0044-6394

IS - 1

ER -

ID: 336122377