TY - JOUR

T1 - Evaluation of a retinal oximetry image quality indicator in patients with cataract

AU - Klefter, Oliver Niels

AU - Erichsen, Jesper Høiberg

AU - Hansen, Mathias Møller

AU - Holm, Lars Morten

AU - Hardarson, Sveinn Hakon

AU - Stefánsson, Einar

AU - Kessel, Line

N1 - Funding Information: The Rigshospitalet Research Foundation (Rigshospitalets Forskningspulje), the Danish Council for Independent Research (Det Frie Forskningsråd, Sundhed og Sygdom, Grant # DFF–7016‐00161), Fight for Sight Denmark and Henry and Astrid Møllers Fond. Publisher Copyright: © 2023 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

PY - 2024

Y1 - 2024

N2 - Purpose: To evaluate a new automated retinal oximetry image quality indicator with cataract as a clinical model. Methods: Sixty-one eyes in 61 patients were imaged by the Oxymap T1 Retinal Oximeter at baseline and 25 eyes were also examined 3 weeks after cataract surgery. Image quality (0–10 on a continuous scale) was compared with standardized AREDS cataract grading and Pentacam lens densitometry. Associations with retinal oximetry measurements and visual acuity were examined. Results: Image quality correlated with total, nuclear and posterior subcapsular cataract grades (ANOVA, p < 0.05), tended to be associated with lens densitometry and it improved from 4.3 ± 1.4 to 5.7 ± 1.0 (p < 0.05) after cataract surgery. Very low image quality, below 3, led to vessel detection failure in retinal oximetry images. Higher image qualities were linearly associated with higher measured retinal oxygen saturations (r = 0.52 in arteries and r = 0.46 in veins; p < 0.001). Conclusion: Retinal oximetry image quality deteriorated with increasing cataract density and improved after cataract surgery, supporting its use as a measure of optical clarity. The numerical quality indicator demonstrated a threshold below which images of poor optical quality should be discarded. Image quality affects the estimates of retinal oximetry parameters and should therefore be included in future analyses.

AB - Purpose: To evaluate a new automated retinal oximetry image quality indicator with cataract as a clinical model. Methods: Sixty-one eyes in 61 patients were imaged by the Oxymap T1 Retinal Oximeter at baseline and 25 eyes were also examined 3 weeks after cataract surgery. Image quality (0–10 on a continuous scale) was compared with standardized AREDS cataract grading and Pentacam lens densitometry. Associations with retinal oximetry measurements and visual acuity were examined. Results: Image quality correlated with total, nuclear and posterior subcapsular cataract grades (ANOVA, p < 0.05), tended to be associated with lens densitometry and it improved from 4.3 ± 1.4 to 5.7 ± 1.0 (p < 0.05) after cataract surgery. Very low image quality, below 3, led to vessel detection failure in retinal oximetry images. Higher image qualities were linearly associated with higher measured retinal oxygen saturations (r = 0.52 in arteries and r = 0.46 in veins; p < 0.001). Conclusion: Retinal oximetry image quality deteriorated with increasing cataract density and improved after cataract surgery, supporting its use as a measure of optical clarity. The numerical quality indicator demonstrated a threshold below which images of poor optical quality should be discarded. Image quality affects the estimates of retinal oximetry parameters and should therefore be included in future analyses.

KW - cataract

KW - image quality

KW - retina

KW - retinal imaging

KW - retinal oximetry

U2 - 10.1111/aos.15747

DO - 10.1111/aos.15747

M3 - Journal article

C2 - 37571978

AN - SCOPUS:85167690052

VL - 102

SP - 312

EP - 317

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 3

ER -