Is fat the future for saving sight? Bioactive lipids and their impact on glaucoma
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Is fat the future for saving sight? Bioactive lipids and their impact on glaucoma. / Kolko, Miriam; Mouhammad, Zaynab Ahmad; Cvenkel, Barbara.
In: Pharmacology & Therapeutics, Vol. 245, 108412, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Is fat the future for saving sight?
T2 - Bioactive lipids and their impact on glaucoma
AU - Kolko, Miriam
AU - Mouhammad, Zaynab Ahmad
AU - Cvenkel, Barbara
N1 - Copyright © 2023. Published by Elsevier Inc.
PY - 2023
Y1 - 2023
N2 - Glaucoma is characterized by a continuous loss of retinal ganglion cells. The cause of glaucoma is associated with an increase in intraocular pressure (IOP), but the underlying pathophysiology is diverse and, in most cases, unknown. There is an indisputable unmet need to identify new pathways involved in glaucoma pathogenesis. Increasing evidence suggests that bioactive lipids may be critical in the development and progression of glaucoma. Preclinical and clinical bioactive lipid targets exist and are being developed. In this review, we aim to shed light on the potential of bioactive lipids for the prevention, diagnosis, prognosis, and treatment of glaucoma by asking the question "is fat the future for saving sight".
AB - Glaucoma is characterized by a continuous loss of retinal ganglion cells. The cause of glaucoma is associated with an increase in intraocular pressure (IOP), but the underlying pathophysiology is diverse and, in most cases, unknown. There is an indisputable unmet need to identify new pathways involved in glaucoma pathogenesis. Increasing evidence suggests that bioactive lipids may be critical in the development and progression of glaucoma. Preclinical and clinical bioactive lipid targets exist and are being developed. In this review, we aim to shed light on the potential of bioactive lipids for the prevention, diagnosis, prognosis, and treatment of glaucoma by asking the question "is fat the future for saving sight".
U2 - 10.1016/j.pharmthera.2023.108412
DO - 10.1016/j.pharmthera.2023.108412
M3 - Review
C2 - 37037408
VL - 245
JO - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
JF - Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
SN - 0163-7258
M1 - 108412
ER -
ID: 345238655