Mitochondrial dysfunction underlying outer retinal diseases

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mitochondrial dysfunction underlying outer retinal diseases. / Lefevere, Evy; Toft-Kehler, Anne Katrine; Vohra, Rupali; Kolko, Miriam; Moons, Lieve; Van Hove, Inge.

In: Mitochondrion, Vol. 36, 2017, p. 66-76.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lefevere, E, Toft-Kehler, AK, Vohra, R, Kolko, M, Moons, L & Van Hove, I 2017, 'Mitochondrial dysfunction underlying outer retinal diseases', Mitochondrion, vol. 36, pp. 66-76. https://doi.org/10.1016/j.mito.2017.03.006

APA

Lefevere, E., Toft-Kehler, A. K., Vohra, R., Kolko, M., Moons, L., & Van Hove, I. (2017). Mitochondrial dysfunction underlying outer retinal diseases. Mitochondrion, 36, 66-76. https://doi.org/10.1016/j.mito.2017.03.006

Vancouver

Lefevere E, Toft-Kehler AK, Vohra R, Kolko M, Moons L, Van Hove I. Mitochondrial dysfunction underlying outer retinal diseases. Mitochondrion. 2017;36:66-76. https://doi.org/10.1016/j.mito.2017.03.006

Author

Lefevere, Evy ; Toft-Kehler, Anne Katrine ; Vohra, Rupali ; Kolko, Miriam ; Moons, Lieve ; Van Hove, Inge. / Mitochondrial dysfunction underlying outer retinal diseases. In: Mitochondrion. 2017 ; Vol. 36. pp. 66-76.

Bibtex

@article{6ba0ade03c4445ff9b35c9c534afb72f,
title = "Mitochondrial dysfunction underlying outer retinal diseases",
abstract = "Dysfunction of photoreceptors, retinal pigment epithelium (RPE) or both contribute to the initiation and progression of several outer retinal disorders. Disrupted M{\"u}ller glia function might additionally subsidize to these diseases. Mitochondrial malfunctioning is importantly associated with outer retina pathologies, which can be classified as primary and secondary mitochondrial disorders. This review highlights the importance of oxidative stress and mitochondrial DNA damage, underlying outer retinal disorders. Indeed, the metabolically active photoreceptors/RPE are highly prone to these hallmarks of mitochondrial dysfunction, indicating that mitochondria represent a weak link in the antioxidant defenses of outer retinal cells.",
keywords = "Age-related Macular Degeneration, Kearns-Sayre Syndrome, Mitochondria, Neuropathy Ataxia Retinitis Pigmentosa Syndrome, Photoreceptors, Retinal pigment epithelium",
author = "Evy Lefevere and Toft-Kehler, {Anne Katrine} and Rupali Vohra and Miriam Kolko and Lieve Moons and {Van Hove}, Inge",
year = "2017",
doi = "10.1016/j.mito.2017.03.006",
language = "English",
volume = "36",
pages = "66--76",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Mitochondrial dysfunction underlying outer retinal diseases

AU - Lefevere, Evy

AU - Toft-Kehler, Anne Katrine

AU - Vohra, Rupali

AU - Kolko, Miriam

AU - Moons, Lieve

AU - Van Hove, Inge

PY - 2017

Y1 - 2017

N2 - Dysfunction of photoreceptors, retinal pigment epithelium (RPE) or both contribute to the initiation and progression of several outer retinal disorders. Disrupted Müller glia function might additionally subsidize to these diseases. Mitochondrial malfunctioning is importantly associated with outer retina pathologies, which can be classified as primary and secondary mitochondrial disorders. This review highlights the importance of oxidative stress and mitochondrial DNA damage, underlying outer retinal disorders. Indeed, the metabolically active photoreceptors/RPE are highly prone to these hallmarks of mitochondrial dysfunction, indicating that mitochondria represent a weak link in the antioxidant defenses of outer retinal cells.

AB - Dysfunction of photoreceptors, retinal pigment epithelium (RPE) or both contribute to the initiation and progression of several outer retinal disorders. Disrupted Müller glia function might additionally subsidize to these diseases. Mitochondrial malfunctioning is importantly associated with outer retina pathologies, which can be classified as primary and secondary mitochondrial disorders. This review highlights the importance of oxidative stress and mitochondrial DNA damage, underlying outer retinal disorders. Indeed, the metabolically active photoreceptors/RPE are highly prone to these hallmarks of mitochondrial dysfunction, indicating that mitochondria represent a weak link in the antioxidant defenses of outer retinal cells.

KW - Age-related Macular Degeneration

KW - Kearns-Sayre Syndrome

KW - Mitochondria

KW - Neuropathy Ataxia Retinitis Pigmentosa Syndrome

KW - Photoreceptors

KW - Retinal pigment epithelium

U2 - 10.1016/j.mito.2017.03.006

DO - 10.1016/j.mito.2017.03.006

M3 - Journal article

C2 - 28365408

AN - SCOPUS:85017396794

VL - 36

SP - 66

EP - 76

JO - Mitochondrion

JF - Mitochondrion

SN - 1567-7249

ER -

ID: 179172659