Phospholipases A2 in ocular homeostasis and diseases
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Phospholipases A2 in ocular homeostasis and diseases. / Wang, Jinmei; Kolko, Miriam.
In: Biochimie, Vol. 92, No. 6, 06.2010, p. 611-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Phospholipases A2 in ocular homeostasis and diseases
AU - Wang, Jinmei
AU - Kolko, Miriam
N1 - Copyright 2010 Elsevier Masson SAS. All rights reserved.
PY - 2010/6
Y1 - 2010/6
N2 - Phospholipases A(2) (PLA(2)s) and its generation of second messengers play an important role in signal transduction, cell proliferation, cell survival and gene expression. At low concentrations mediators of PLA(2) activity have a variety of physiological effects whereas high levels of PLA(2) and its metabolites are generated during pathological conditions. The eye is an immunoprivileged organ with tight barriers and a complex interplay among various cell types. Overall, vision is a complex process which requires a clear corneal surface and lens, and thereby a clear pathway through the eye into the retina. In the retina the photoreceptors transmit light into neuronal signals that are finally transferred to the brain to perceive an image. Growing knowledge of a role of PLA(2) in ocular diseases appears and the present review aims to summarize the vast literature on PLA(2) in the normal eye as well as during pathological conditions.
AB - Phospholipases A(2) (PLA(2)s) and its generation of second messengers play an important role in signal transduction, cell proliferation, cell survival and gene expression. At low concentrations mediators of PLA(2) activity have a variety of physiological effects whereas high levels of PLA(2) and its metabolites are generated during pathological conditions. The eye is an immunoprivileged organ with tight barriers and a complex interplay among various cell types. Overall, vision is a complex process which requires a clear corneal surface and lens, and thereby a clear pathway through the eye into the retina. In the retina the photoreceptors transmit light into neuronal signals that are finally transferred to the brain to perceive an image. Growing knowledge of a role of PLA(2) in ocular diseases appears and the present review aims to summarize the vast literature on PLA(2) in the normal eye as well as during pathological conditions.
KW - Animals
KW - Corneal Diseases
KW - Eye Diseases
KW - Homeostasis
KW - Humans
KW - Neurons
KW - Phospholipases A2
KW - Photoreceptor Cells
KW - Retina
KW - Signal Transduction
U2 - 10.1016/j.biochi.2010.04.007
DO - 10.1016/j.biochi.2010.04.007
M3 - Journal article
C2 - 20403410
VL - 92
SP - 611
EP - 619
JO - Biochimie
JF - Biochimie
SN - 0300-9084
IS - 6
ER -
ID: 128614676