Protein changes in the retina following experimental retinal detachment in rabbits
Research output: Contribution to journal › Journal article › Research › peer-review
Retinal detachment leads to the widespread cellular remodeling of the retina. The purpose of this study was to identify protein changes that accompany these cellular alterations by comparing the proteomic profiles of sham and experimentally detached rabbit retina. Elucidation of the proteins most dramatically affected by retinal detachment would add further understanding to the pathophysiology of this condition, and potentially identify therapeutic targets useful in preventing the deleterious effects of detachment, including photoreceptor cell death and the activation of non-neuronal microglial and Müller cells.
Original language | English |
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Journal | Molecular Vision |
Volume | 17 |
Pages (from-to) | 2634-48 |
Number of pages | 15 |
ISSN | 1090-0535 |
Publication status | Published - 2011 |
- Animals, Blotting, Western, Chromatography, Liquid, Disease Models, Animal, Electrophoresis, Gel, Two-Dimensional, Eye Proteins, Gene Expression Profiling, Proteomics, Rabbits, Retina, Retinal Detachment, Tandem Mass Spectrometry
Research areas
ID: 38082606