The role of inflammation in the pathogenesis of glaucoma

Department of Clinical Medicine

The role of inflammation in the pathogenesis of glaucoma

Research output: Contribution to journal › Journal article › Research › peer-review

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The role of inflammation in the pathogenesis of glaucoma. / Vohra, Rupali; Tsai, James C; Kolko, Miriam.

In: Survey of Ophthalmology, Vol. 58, No. 4, 19.06.2013, p. 311-20.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vohra, R, Tsai, JC & Kolko, M 2013, 'The role of inflammation in the pathogenesis of glaucoma', Survey of Ophthalmology, vol. 58, no. 4, pp. 311-20. https://doi.org/10.1016/j.survophthal.2012.08.010

APA

Vohra, R., Tsai, J. C., & Kolko, M. (2013). The role of inflammation in the pathogenesis of glaucoma. Survey of Ophthalmology, 58(4), 311-20. https://doi.org/10.1016/j.survophthal.2012.08.010

Vancouver

Vohra R, Tsai JC, Kolko M. The role of inflammation in the pathogenesis of glaucoma. Survey of Ophthalmology. 2013 Jun 19;58(4):311-20. https://doi.org/10.1016/j.survophthal.2012.08.010

Author

Vohra, Rupali ; Tsai, James C ; Kolko, Miriam. / The role of inflammation in the pathogenesis of glaucoma. In: Survey of Ophthalmology. 2013 ; Vol. 58, No. 4. pp. 311-20.

Bibtex

@article{75871d29583a45ac801ad44a2ed4730c,

title = "The role of inflammation in the pathogenesis of glaucoma",

abstract = "Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.",

keywords = "Animals, Anoxia, Axons, Cell Death, Glaucoma, Humans, Inflammation, Oxidative Stress, Retinal Ganglion Cells",

author = "Rupali Vohra and Tsai, {James C} and Miriam Kolko",

year = "2013",

month = jun,

day = "19",

doi = "10.1016/j.survophthal.2012.08.010",

language = "English",

volume = "58",

pages = "311--20",

journal = "Survey of Ophthalmology",

issn = "0039-6257",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - The role of inflammation in the pathogenesis of glaucoma

AU - Vohra, Rupali

AU - Tsai, James C

AU - Kolko, Miriam

PY - 2013/6/19

Y1 - 2013/6/19

N2 - Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.

AB - Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC death. Previously, glaucoma was defined by high intraocular pressure (IOP); during the past decade, however, glaucoma specialists have acknowledged that elevated IOP is the most important risk factor for glaucoma, but does not define the disease. Other factors such as genetics, blood flow, and excitotoxicity are suggested as potential causal factors for progressive RGC death observed in glaucoma. We review recent studies elucidating a possible role of low-grade inflammation as a causal factor in the pathogenesis of glaucoma.

KW - Animals

KW - Anoxia

KW - Axons

KW - Cell Death

KW - Glaucoma

KW - Humans

KW - Inflammation

KW - Oxidative Stress

KW - Retinal Ganglion Cells

U2 - 10.1016/j.survophthal.2012.08.010

DO - 10.1016/j.survophthal.2012.08.010

M3 - Journal article

C2 - 23768921

VL - 58

SP - 311

EP - 320

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

SN - 0039-6257

IS - 4

ER -

ID: 120197583