Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage
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The poor regenerative capacity of articular cartilage presents a major clinical challenge and may relate to a limited turnover of the cartilage collagen matrix. However, the collagen turnover rate during life is not clear, and it is debated whether osteoarthritis (OA) can influence it. Using the carbon-14 ((14)C) bomb-pulse method, life-long replacement rates of collagen were measured in tibial plateau cartilage from 23 persons born between 1935 and1997 (15 and 8 persons with OA and healthy cartilage, respectively). The (14)C levels observed in cartilage collagen showed that, virtually, no replacement of the collagen matrix happened after skeletal maturity and that neither OA nor tissue damage, per se, influenced collagen turnover. Regional differences in (14)C content across the joint surface showed that cartilage collagen located centrally on the joint surface is formed several years earlier than collagen located peripherally. The collagen matrix of human articular cartilage is an essentially permanent structure that has no significant turnover in adults, even with the occurrence of disease.
Original language | English |
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Article number | 346ra90 |
Journal | Science Translational Medicine |
Volume | 8 |
Issue number | 346 |
ISSN | 1946-6234 |
DOIs | |
Publication status | Published - 6 Jul 2016 |
- Journal Article
Research areas
ID: 172926734