Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1
Research output: Contribution to journal › Journal article › Research › peer-review
Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis. It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expression of MMPs is lacking. This study targets the angiogenic process by investigation of tumor expression of MMP-2, MMP-9, and tissue inhibitors of metalloproteinase (TIMP)-1. A possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored.
| Original language | English |
|---|---|
| Journal | Laryngoscope |
| Volume | 120 |
| Issue number | 4 |
| Pages (from-to) | 657-62 |
| Number of pages | 6 |
| ISSN | 0023-852X |
| DOIs | |
| Publication status | Published - 2010 |
- Adult, Aged, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Middle Aged, Neoplasm Staging, Neovascularization, Pathologic, Neuroma, Acoustic, Prospective Studies, RNA, Neoplasm, Tissue Inhibitor of Metalloproteinase-1
Research areas
ID: 41800723