Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort
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Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort. / Reznitsky, Martin; Petersen, Mette Marie Babiel Schmidt; West, Niels; Stangerup, Sven Eric; Cayé-Thomasen, Per.
In: Clinical Epidemiology, Vol. 11, 11.2019, p. 981-986.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort
AU - Reznitsky, Martin
AU - Petersen, Mette Marie Babiel Schmidt
AU - West, Niels
AU - Stangerup, Sven Eric
AU - Cayé-Thomasen, Per
PY - 2019/11
Y1 - 2019/11
N2 - Objective: Reports on the epidemiology of vestibular schwannoma (VS) indicate an increase in diagnosed cases, often based on selected materials over a limited period of time. This report presents prospective 40-year epidemiological data from an unselected national cohort of all patients diagnosed with a VS in Denmark since 1976. Study-design: Data on gender, age, tumor localization and size registered during the period 1976–2015 were retrieved. Results: 3637 new cases of VS were diagnosed during the 40-year period. The annual number of diagnosed VS increased from 14 in 1976 to 193 in 2015. Mean extrameatal tumor size decreased from 26mm in 1976 to 13.4mm in 2015. Large and giant tumors were more frequent during the first decades, whereas predominantly smaller tumors were diagnosed during the recent years. Median age at diagnosis increased gradually from 49.2 years in 1976 to 60 years in 2015. Conclusion: Over the past 40 years, the incidence rate of vestibular schwannomas has increased steadily from 3 VS/million/year to 34 VS/million/year, primarily due to easier access to improved diagnostics and the finding of more tumors in older people. Concurrently, the diagnostic tumor size has decreased from 26mm to 7mm, and the age at diagnosis has increased from 49 to 60 years.
AB - Objective: Reports on the epidemiology of vestibular schwannoma (VS) indicate an increase in diagnosed cases, often based on selected materials over a limited period of time. This report presents prospective 40-year epidemiological data from an unselected national cohort of all patients diagnosed with a VS in Denmark since 1976. Study-design: Data on gender, age, tumor localization and size registered during the period 1976–2015 were retrieved. Results: 3637 new cases of VS were diagnosed during the 40-year period. The annual number of diagnosed VS increased from 14 in 1976 to 193 in 2015. Mean extrameatal tumor size decreased from 26mm in 1976 to 13.4mm in 2015. Large and giant tumors were more frequent during the first decades, whereas predominantly smaller tumors were diagnosed during the recent years. Median age at diagnosis increased gradually from 49.2 years in 1976 to 60 years in 2015. Conclusion: Over the past 40 years, the incidence rate of vestibular schwannomas has increased steadily from 3 VS/million/year to 34 VS/million/year, primarily due to easier access to improved diagnostics and the finding of more tumors in older people. Concurrently, the diagnostic tumor size has decreased from 26mm to 7mm, and the age at diagnosis has increased from 49 to 60 years.
KW - Acoustic neuroma
KW - Age
KW - Incidence
KW - Tumor localization
KW - Tumor size
U2 - 10.2147/CLEP.S218670
DO - 10.2147/CLEP.S218670
M3 - Journal article
C2 - 31807080
AN - SCOPUS:85075182583
VL - 11
SP - 981
EP - 986
JO - Clinical Epidemiology
JF - Clinical Epidemiology
SN - 1179-1349
ER -
ID: 241488797