Incidence and prevalence of multiple endocrine neoplasia 2a in denmark 1901–2014: A nationwide study
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Incidence and prevalence of multiple endocrine neoplasia 2a in denmark 1901–2014 : A nationwide study. / Mathiesen, Jes Sloth; Kroustrup, Jens Peter; Vestergaard, Peter; Stochholm, Kirstine; Poulsen, Per Løgstrup; Rasmussen, Åse Krogh; Feldt-Rasmussen, Ulla; Schytte, Sten; Pedersen, Henrik Baymler; Hahn, Christoffer Holst; Bentzen, Jens; Möller, Sören; Gaustadnes, Mette; Rossing, Maria; Nielsen, Finn Cilius; Brixen, Kim; Frederiksen, Anja Lisbeth; Godballe, Christian.
In: Clinical Epidemiology, Vol. 10, 2018, p. 1479-1487.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Incidence and prevalence of multiple endocrine neoplasia 2a in denmark 1901–2014
T2 - A nationwide study
AU - Mathiesen, Jes Sloth
AU - Kroustrup, Jens Peter
AU - Vestergaard, Peter
AU - Stochholm, Kirstine
AU - Poulsen, Per Løgstrup
AU - Rasmussen, Åse Krogh
AU - Feldt-Rasmussen, Ulla
AU - Schytte, Sten
AU - Pedersen, Henrik Baymler
AU - Hahn, Christoffer Holst
AU - Bentzen, Jens
AU - Möller, Sören
AU - Gaustadnes, Mette
AU - Rossing, Maria
AU - Nielsen, Finn Cilius
AU - Brixen, Kim
AU - Frederiksen, Anja Lisbeth
AU - Godballe, Christian
PY - 2018
Y1 - 2018
N2 - Background: The incidence and prevalence of multiple endocrine neoplasia 2A (MEN2A) have only been reported once in a nationwide setting. However, it is unclear whether the figures are representative of other populations, as the major component of the syndrome, hereditary medullary thyroid carcinoma (MTC), has been reported as rare in the same country. We conducted a nationwide retrospective cohort study of MEN2A in Denmark from 1901 to 2014, aiming to describe the incidence and prevalence. Methods: This study included 250 unique MEN2A patients born or resident in Denmark before December 31, 2014. Patients were identified through the Danish REarranged during Transfection (RET) cohort, linkage of MEN2A pedigrees, the Danish MTC cohort, a nationwide collaboration of MEN2 centers, cross-checking of other relevant cohorts, and a systematic literature search. Results: The incidence from 1971 to 2000 was 28 (95% CI: 21–37) per million live births per year. Incidence for the specific mutations or for the overall MEN2A group did not change significantly from 1901 to 2014 (P>0.05). Point prevalence at January 1, 2015, was 24 per million (95% CI: 20–28). Conclusion: The incidence and prevalence of MEN2A in Denmark seem higher than those reported in other countries. This is likely explained by the Danish C611Y founder effect. Also, our data indicate no significant change in MEN2A incidence during the last century.
AB - Background: The incidence and prevalence of multiple endocrine neoplasia 2A (MEN2A) have only been reported once in a nationwide setting. However, it is unclear whether the figures are representative of other populations, as the major component of the syndrome, hereditary medullary thyroid carcinoma (MTC), has been reported as rare in the same country. We conducted a nationwide retrospective cohort study of MEN2A in Denmark from 1901 to 2014, aiming to describe the incidence and prevalence. Methods: This study included 250 unique MEN2A patients born or resident in Denmark before December 31, 2014. Patients were identified through the Danish REarranged during Transfection (RET) cohort, linkage of MEN2A pedigrees, the Danish MTC cohort, a nationwide collaboration of MEN2 centers, cross-checking of other relevant cohorts, and a systematic literature search. Results: The incidence from 1971 to 2000 was 28 (95% CI: 21–37) per million live births per year. Incidence for the specific mutations or for the overall MEN2A group did not change significantly from 1901 to 2014 (P>0.05). Point prevalence at January 1, 2015, was 24 per million (95% CI: 20–28). Conclusion: The incidence and prevalence of MEN2A in Denmark seem higher than those reported in other countries. This is likely explained by the Danish C611Y founder effect. Also, our data indicate no significant change in MEN2A incidence during the last century.
KW - Denmark
KW - Incidence
KW - Multiple endocrine neoplasia 2A
KW - Prevalence
U2 - 10.2147/CLEP.S174606
DO - 10.2147/CLEP.S174606
M3 - Journal article
C2 - 30349395
AN - SCOPUS:85057767451
VL - 10
SP - 1479
EP - 1487
JO - Clinical Epidemiology
JF - Clinical Epidemiology
SN - 1179-1349
ER -
ID: 217252177