Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


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  1. Published

    Cryptorchidism as part of the testicular dysgenesis syndrome: the environmental connection

    Main, Katharina Maria, Skakkebæk, Niels Erik & Toppari, J., 2009, In: Endocrine Development. 14, p. 167-73 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    The impact of gender and puberty on reference values for urinary growth hormone excretion: a study of 3 morning urine samples in 517 healthy children and adults

    Main, Katharina Maria, Jarden, M., Angelo, L., Dinesen, B. I., Hertel, N., Juul, Anders, Müller, J. & Skakkebæk, Niels Erik, 1994, In: Journal of Clinical Endocrinology and Metabolism. 79, 3, p. 865-71 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Genital anomalies in boys and the environment

    Main, Katharina Maria, Skakkebæk, Niels Erik, Virtanen, H. E. & Toppari, J., 1 Apr 2010, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 24, 2, p. 279-89 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age

    Main, Katharina Maria, Mortensen, G. K., Kaleva, M. M., Boisen, K. A., Damgaard, I. N., Chellakooty, M., Schmidt, I. M., Suomi, A., Virtanen, H. E., Petersen, J. H., Andersson, A., Toppari, J. & Skakkebæk, Niels Erik, 2006, In: Environmental Health Perspectives. 114, 2, p. 270-276 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number

    Mau Kai, C., Juul, Anders, McElreavey, K., Ottesen, A. M., Garn, I. D., Main, Katharina Maria, Loft, A., Jørgensen, N., Skakkebæk, Niels Erik, Andersen, A. N. & Rajpert-De Meyts, E., 2008, In: Human Reproduction. 23, 7, p. 1669-1678 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection

    Mau Kai, C., Main, Katharina Maria, Andersen, A. N., Loft, A., Skakkebæk, Niels Erik & Juul, Anders, 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 7, p. 2598-603 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Developmental origins of testicular germ cell tumours (TGCT)

    Meyts, E. R., Jørgensen, A., Jørgensen, N., Almstrup, Kristian & Skakkebæk, Niels Erik, Sep 2019, In: European Urology Supplements. 18, 4, p. 11

    Research output: Contribution to journal › Conference abstract in journal › Research

  8. Diagnostic markers for germ cell neoplasms: From placental-like alkaline phosphatase to micro-RNAs

    Meyts, E. R. D., Nielsen, J. E., Skakkebæk, Niels Erik & Almstrup, Kristian, 8 Oct 2015, In: Folia Histochemica et Cytobiologica. 53, 3, p. 177-188 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Testicular Dysgenesis Syndrome and Carcinoma In Situ Testis

    Meyts, E. R., Almstrup, Kristian & Skakkebæk, Niels Erik, 17 Sep 2012, Atlas on the Human Testis.. Springer London, p. 159-178

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  10. Published

    The Testis in Childhood Between Birth and Puberty

    Meyts, E. R., Almstrup, Kristian, Nielsen, J. E. & Skakkebæk, Niels Erik, 2013, Atlas on the Human Testis.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  11. Published

    Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia

    Mieritz, M. G., Frederiksen, H., Sørensen, K., Aksglaede, L., Mouritsen, A., Hagen, C. P., Skakkebæk, Niels Erik, Andersson, A. & Juul, Anders, 2012, In: International Journal of Andrology. 35, 3, p. 227-35 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study

    Mogensen, D. M., Pihl, M. B., Skakkebæk, Niels Erik, Andersen, H. R., Juul, Anders, Kyhl, H. B., Swan, S., Kristensen, D. M., Andersen, M. S., Lind, D. V. & Jensen, T. K., 2017, In: Environmental Health. 16, 8 p., 68.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Central Precocious Puberty in two Boys with Prader-Willi Syndrome on Growth Hormone Treatment

    Monai, E., Johansen, A., Clasen-Linde, E., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, Main, Katharina Maria, Jørgensen, A. & Jensen, R. B., 2019, In: AACE Clinical Case Reports. 5, 6, p. e352-e356

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Predicting and monitoring of growth in children with short stature during the first year of growth hormone treatment

    Mortensen, H. B., Main, Katharina Maria, Michaelsen, Kim F., Kastrup, K. W., Jørgensen, J. T. & Skakkebæk, Niels Erik, 1991, In: Acta Paediatrica Scandinavica. 80, 12, p. 1150-1157 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Vurdering af knemometri som metode til kontrol af højdetilvækst hos væksthæmmede børn under et års væksthormonbehandling

    Mortensen, H. B., Main, Katharina Maria, Michaelsen, Kim F., Kastrup, K. W., Jørgensen, J. T. & Skakkebæk, Niels Erik, 1993, In: Ugeskrift for læger. 155, 15, p. 1135-1139 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Germ cell neoplasia in situ and preserved fertility despite suppressed gonadotropins in a patient with testotoxicosis

    Mortensen, L. J., Jensen, M. B., Christiansen, P., Rønholt, A. M., Jørgensen, A., Frederiksen, H., Nielsen, J. E., Loya, Anand Chainsukh, Grønkær Toft, B., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Juul, Anders, 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 12, p. 4411-4416 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Nedsatte serum koncentrationer af insulin-like growth factor hos patienter med cystisk fibrose

    Mosfeldt-Laursen, E., Juul, Anders, Lanng, S., Højby, N., Koch, C., Müller, J. & Skakkebæk, Niels Erik, 1996, In: Ugeskrift for Laeger. 158, 38, p. 5300-5302 2 p.

    Research output: Contribution to journal › Journal article › Research

  18. Published

    Urinary phthalates from 168 girls and boys measured twice a year during a 5-year period

    Mouritsen, Annette Korsholm, Frederiksen, H., Sørensen, K., Aksglæde, L., Hagen, C., Skakkebæk, Niels Erik, Main, Katharina Maria, Andersson, A. M. & Juul, Anders, 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 9, p. 3755-3764 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty

    Mouritsen, Annette Korsholm, Aksglaede, L., Sørensen, K., Mogensen, S. S., Leffers, H., Main, Katharina Maria, Frederiksen, H., Andersson, A., Skakkebæk, Niels Erik & Juul, Anders, 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 346-59 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Short-term effect of recombinant human growth hormone in patients with alcoholic cirrhosis

    Møller, S., Becker, U., Grønbaek, M., Juul, Anders, Winkler, K. & Skakkebæk, Niels Erik, 1994, In: Journal of Hepatology. 21, 5, p. 710-7 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Den prognostiske værdi af insulinlignende vækstfaktor i (IGF-I) og bindingsproteinet IGFBP-3 ved alkoholistisk leversygdom

    Møller, S., Becker, U., Juul, Anders, Skakkebæk, Niels Erik, Christensen, E. & EMALD-gruppen, E., 1997, In: Ugeskrift for Laeger. 159, 30, p. 4636-4640 4 p.

    Research output: Contribution to journal › Journal article › Research

  22. Prognostic value of insulinlike growth factor I and its binding protein in patients with alcohol-induced liver disease

    The EMALD Group, T. E. G., May 1996, In: Hepatology. 23, 5, p. 1073-1078 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Hormonal changes during GnRH analogue therapy in children with central precocious puberty

    Müller, J., Juul, Anders, Andersson, A. M., Sehested, A. & Skakkebæk, Niels Erik, 2000, In: Journal of Pediatric Endocrinology and Metabolism. 13 Suppl 1, p. 739-46 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Growth hormone treatment during pregnancy in a growth hormone-deficient woman

    Müller, J., Starup, J., Christiansen, J. S., Jørgensen, J. O., Juul, Anders & Skakkebæk, Niels Erik, 1995, In: European Journal of Endocrinology. 132, 6, p. 727-9 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Analysis of the sex-determining region of the Y chromosome (SRY) in sex reversed patients: point-mutation in SRY causing sex-reversion in a 46,XY female

    Müller, J., Schwartz, M. & Skakkebæk, Niels Erik, 1 Jul 1992, In: Journal of Clinical Endocrinology and Metabolism. 75, 1, p. 331-3 3 p.

    Research output: Contribution to journal › Journal article › Research

  26. Published

    Variant PNLDC1, Defective piRNA Processing, and Azoospermia

    Nagirnaja, L., Mørup, N., Nielsen, J. E., Stakaitis, R., Golubickaite, I., Oud, M. S., Winge, S. B., Carvalho, F., Aston, K. I., Khani, F., Van Der Heijden, G. W., Marques, C. J., Skakkebæk, Niels Erik, Rajpert–de Meyts, E., Schlegel, P. N., Jørgensen, N., Veltman, J. A., Lopes, A. M., Conrad, D. F. & Almstrup, Kristian, 19 Aug 2021, In: New England Journal of Medicine. 385, 8, p. 707-719 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study

    Nassan, F. L., Coull, B. A., Gaskins, A. J., Williams, M. A., Skakkebæk, Niels Erik, Ford, J. B., Ye, X., Calafat, A. M., Braun, J. M. & Hauser, R., 2017, In: Environmental Health Perspectives. 125, 8, 11 p., 087012.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    A crossover-crossback prospective study of dibutyl-phthalate exposure from mesalamine medications and serum reproductive hormones in men

    Nassan, F. L., Coull, B. A., Skakkebæk, Niels Erik, Andersson, A., Williams, M. A., Mínguez-Alarcón, L., Krawetz, S. A., Hall, J. E., Hait, E. J., Korzenik, J. R., Ford, J. B., Moss, A. C. & Hauser, R., 2018, In: Environmental Research. 160, p. 121-131 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    A crossover-crossback prospective study of dibutyl-phthalate exposure from mesalamine medications and semen quality in men with inflammatory bowel disease

    Nassan, F. L., Coull, B. A., Skakkebæk, Niels Erik, Williams, M. A., Dadd, R., Mínguez-Alarcón, L., Krawetz, S. A., Hait, E. J., Korzenik, J. R., Moss, A. C., Ford, J. B. & Hauser, R., Oct 2016, In: Environment International. 95, p. 120-30 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Onset of the release of spermatozia (supermarche) in boys in relation to age, testicular growth, pubic hair, and height

    Nielsen, C. T., Skakkebæk, Niels Erik, Richardson, D. W., Darling, J. A. B., Hunter, W. M., Jørgensen, M., Nielsen, A., Ingerslev, O., Keiding, N. & Müller, J., 1 Mar 1986, In: Journal of Clinical Endocrinology and Metabolism. 62, 3, p. 532-535 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samples

    Nielsen, J. E., Kristensen, D. M., Almstrup, Kristian, Jørgensen, A., Olesen, I. A., Jacobsen, G. K., Horn, T., Skakkebæk, Niels Erik, Leffers, H., Rajpert-De Meyts, E. & Jacobsen, G., 2012, In: Andrologia. p. 78-85 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis

    Nielsen, J. E., Hansen, M. A., Jørgensen, M., Tanaka, M., Almstrup, Kristian, Skakkebæk, Niels Erik & Leffers, H., 2003, In: European Journal of Histochemistry. 47, 3, p. 215-222 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Nielsen, J. E., Rolland, A. D., Rajpert-De Meyts, E., Janfelt, Christian, Jørgensen, A., Winge, S. B., Kristensen, D. M., Juul, Anders, Chalmel, F., Jégou, B. & Skakkebæk, Niels Erik, 2019, In: Scientific Reports. 9, 1, 14 p., 12866.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Possible involvement of the glucocorticoid receptor (NR3C1) and selected NR3C1 gene variants in regulation of human testicular function

    Nordkap, L., Almstrup, Kristian, Nielsen, J. E., Bang, A. K., Priskorn, L., Krause, M., Holmboe, S. A., Winge, S. B., Egeberg Palme, D. L., Mørup, N., Petersen, Jørgen Holm, Juul, A., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Jørgensen, N., Nov 2017, In: Andrology. 5, 6, p. 1105-1114 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Impact of psychological stress measured in three different scales on testis function: A cross-sectional study of 1362 young men

    Nordkap, L., Priskorn, L., Bräuner, E. V., Hansen, Åse Marie, Kirstine Bang, A., Holmboe, S. A., Winge, S. B., Egeberg Palme, D. L., Mørup, N., Skakkebæk, Niels Erik, Kold Jensen, T. & Jørgensen, N., 2020, In: Andrology. 8, 6, p. 1674-1686 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Psychological stress and testicular function: a cross-sectional study of 1,215 Danish men

    Nordkap, L., Jensen, T. K., Hansen, Åse Marie, Lassen, T. H., Bang, A. K., Joensen, Ulla Nordström, Jensen, Martin Blomberg, Skakkebæk, Niels Erik & Jørgensen, N., Jan 2016, In: Fertility and Sterility. 105, 1, p. 174-187.e2 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Translational repression of E2F1 mRNA in carcinoma in situ and normal testis correlates with expression of the miR-17-92 cluster

    Novotny, G. W., Sonne, Si Brask, Nielsen, J. E., Jonstrup, S. P., Hansen, M. A., Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Kjems, J. & Leffers, H., 2007, In: Cell Death and Differentiation. 14, 4, p. 879-82 3 p.

    Research output: Contribution to journal › Letter › Research

  38. Published

    Analysis of gene expression in normal and neoplastic human testis: new roles of RNA

    Novotny, G. W., Nielsen, J. E., Sonne, Si Brask, Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Leffers, H. & Sonne, Si Brask, 2007, In: International Journal of Andrology. 30, 4, p. 316-327

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Continuation of growth hormone (GH) therapy in GH-deficient patients during transition from childhood to adulthood: impact on insulin sensitivity and substrate metabolism

    Nørrelund, H., Vahl, N., Juul, Anders, Møller, N., Alberti, K. G., Skakkebæk, Niels Erik, Christiansen, J. S. & Jørgensen, J. O., 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, 5, p. 1912-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Environment, testicular dysgenesis and carcinoma in situ testis

    Olesen, I. A., Sonne, Si Brask, Hoei-Hansen, C. E., Rajpert-DeMeyts, E. & Skakkebæk, Niels Erik, 2007, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 21, 3, p. 462-78 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Clinical, genetic, biochemical, and testicular biopsy findings among 1,213 men evaluated for infertility

    Olesen, I. A., Andersson, A., Aksglaede, L., Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Jørgensen, N. & Juul, Anders, Jan 2017, In: Fertility and Sterility. 107, 1, p. 74-82.e7

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)

    Olsson, A., Togawa, K., Schüz, J., Le Cornet, C., Fervers, B., Oksbjerg Dalton, S., Pukkala, E., Maria Feychting, M. F., Skakkebæk, Niels Erik & Hansen, J., 2018, In: Scandinavian Journal of Work, Environment & Health. 44, 6, p. 658-669

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Semen quality in sub-fertile range for a significant proportion of young men from the general German population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig

    Paasch, U., Salzbrunn, A., Glander, H. J., Plambeck, K., Salzbrunn, H., Grunewald, S., Stucke, J., Vierula, M., Jorgensen, N. & Skakkebæk, Niels Erik, 2008, In: International Journal of Andrology. 31, 2, p. 93-102 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration

    Parent, A., Teilmann, Grete Katrine, Juul, Anders, Skakkebæk, Niels Erik, Toppari, J. & Bourguignon, J., 2003, In: Endocrine Reviews. 24, 5, p. 668-93 26 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Serum levels of insulin-like growth factor-1 in first trimester of diabetic pregnancy: relation to early growth delay

    Pedersen, J. F., Juul, Anders, Mølsted-Pedersen, L. & Skakkebæk, Niels Erik, 1995, In: B J O G. 102, 11, p. 927-8 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Semen quality improves marginally during young adulthood: a longitudinal follow-up study

    Perheentupa, A., Sadov, S., Rönkä, R., Virtanen, H. E., Rodprasert, W., Vierula, M., Jørgensen, N., Skakkebæk, Niels Erik & Toppari, J., 2016, In: Human Reproduction. 31, 3, p. 502-10 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Impaired testicular function in patients with carcinoma-in-situ of the testis

    Petersen, P. M., Giwercman, A., Hansen, S. W., Berthelsen, Jens, Daugaard, G., Rørth, M. & Skakkebæk, Niels Erik, 1999, In: Journal of Clinical Oncology. 17, 1, p. 173-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Endocrine function in patients treated for carcinoma in situ in the testis with irradiation

    Petersen, P. M., Daugaard, G., Rørth, M. & Skakkebæk, Niels Erik, 2003, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 111, 1, p. 93-8; discussion 98-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population

    Priskorn, L., Bang, A. K., Nordkap, L., Krause, M., Mendiola, J., Jensen, T. K., Juul, Anders, Skakkebæk, Niels Erik, Swan, S. H. & Jørgensen, Niklas Rye, 1 Jan 2019, In: Human reproduction (Oxford, England). 34, 1, p. 12-24 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Average sperm count remains unchanged despite reduction in maternal smoking: results from a large cross-sectional study with annual investigations over 21 years

    Priskorn, L., Nordkap, L., Bang, A. K., Krause, M., Holmboe, S. A., Egeberg Palme, D. L., Winge, S. B., Mørup, N., Carlsen, E., Joensen, Ulla Nordström, Blomberg Jensen, M., Main, Katharina Maria, Juul, Anders, Skakkebæk, Niels Erik, Jensen, T. K. & Jørgensen, N., 2018, In: Human Reproduction. 33, 6, p. 998-1008 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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