Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


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  1. Published

    A Brief Review of the Link between Environment and Male Reproductive Health: Lessons from Studies of Testicular Germ Cell Cancer

    Skakkebæk, Niels Erik, 2016, In: Hormone Research in Paediatrics. 86, 4, p. 240-246 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  2. Published

    Populations, decreasing fertility, and reproductive health

    Skakkebæk, Niels Erik, Jørgensen, N., Andersson, A., Juul, Anders, Main, Katharina Maria, Jensen, T. K. & Toppari, J., 13 Apr 2019, In: Lancet Oncology. 393, 10180, p. 1500-1501 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  3. Published

    Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility

    Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Buck Louis, G. M., Toppari, J., Andersson, A., Eisenberg, M. L., Jensen, T. K., Jørgensen, N., Swan, S. H., Sapra, K. J., Ziebe, S., Priskorn, L. & Juul, Anders, Jan 2016, In: Physiological Reviews. 96, 1, p. 55-97 43 p.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    Normal reference ranges for semen quality and their relations to fecundity

    Skakkebæk, Niels Erik, 1 Jan 2010, In: Asian Journal of Andrology. 12, 1, p. 95-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Sperm counts, testicular cancers, and the environment

    Skakkebæk, Niels Erik, 10 Oct 2017, In: B M J. 359, j4517.

    Research output: Contribution to journal › Editorial › Research

  6. Published

    Is human fecundity declining?

    Skakkebæk, Niels Erik, Jørgensen, N., Main, Katharina Maria, Rajpert-De Meyts, E., Leffers, H., Andersson, A., Juul, Anders, Carlsen, E., Mortensen, G. K., Jensen, T. K. & Toppari, J., 1 Feb 2006, In: International Journal of Andrology. 29, 1, p. 2-11 10 p.

    Research output: Contribution to journal › Journal article › Research

  7. Published

    Commentary: sperm counts, data responsibility, and good scientific practice

    Skakkebæk, Niels Erik, Andersson, A., Juul, Anders, Jensen, T. K., Almstrup, Kristian, Toppari, J. & Jørgensen, N., 1 Sep 2011, In: Epidemiology. 22, 5, p. 620-1 2 p.

    Research output: Contribution to journal › Letter › Research

  8. Published

    The exposure of fetuses and children to endocrine disrupting chemicals: a European Society for Paediatric Endocrinology (ESPE) and Pediatric Endocrine Society (PES) call to action statement

    Skakkebæk, Niels Erik, Toppari, J., Söder, O., Gordon, C. M., Divall, S. & Draznin, M., 1 Oct 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 10, p. 3056-8 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Environmental factors in declining human fertility

    Skakkebæk, Niels Erik, Lindahl-Jacobsen, R., Levine, H., Andersson, A., Jørgensen, N., Main, Katharina Maria, Lidegaard, Øjvind, Priskorn, Lærke, Holmboe, S. A., Bräuner, E. V., Almstrup, Kristian, Franca, L. R., Znaor, A., Kortenkamp, A., Hart, R. J. & Juul, Anders, 2022, In: Nature Reviews Endocrinology. 18, p. 139–157

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis

    Skakkebæk, Niels Erik, Holm, M., Hoei-Hansen, C., Jørgensen, N. & Rajpert-De Meyts, E., 1 Jan 2003, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 111, 1, p. 1-9; discussion 9-11

    Research output: Contribution to journal › Journal article › Research

  11. Published

    Changes in semen and the testis

    Skakkebæk, Niels Erik & Keiding, N., 19 Nov 1994, In: BMJ. 309, 6965, p. 1316-1317 2 p.

    Research output: Contribution to journal › Editorial › Research

  12. Published

    Mere Testikelkræft og dårlig sædkvalitet

    Skakkebæk, Niels Erik, 2008, In: Tidsskrift for Den norske lægeforening. 128, p. 554-554

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Selection Biases in Semen Study?

    Skakkebæk, Niels Erik, Giwercman, A., Jensen, T. K., Carlsen, E., Jørgensen, N. & Keiding, N., Jun 1998, In: Fertility & Sterility. 69, 6, p. 1158-1159 2 p.

    Research output: Contribution to journal › Comment/debate › Research

  14. Published

    Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities

    Slama, R., Eustache, F., Ducot, B., Jensen, T. K., Jørgensen, N., Horte, A., Irvine, S., Suominen, J., Andersen, A. G., Auger, J., Vierula, M., Toppari, J., Andersen, A. N., Keiding, N., Skakkebæk, Niels Erik, Spira, A. & Jouannet, P., 2002, In: Human Reproduction. 17, 2, p. 503-515 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer

    Smarr, M. M., Sapra, K. J., Gemmill, A., Kahn, L. G., Wise, L. A., Lynch, C. D., Factor-Litvak, P., Mumford, S. L., Skakkebæk, Niels Erik, Slama, R., Lobdell, D. T., Stanford, J. B., Jensen, T. K., Boyle, E. H., Eisenberg, M. L., Turek, P. J., Sundaram, R., Thoma, M. E. & Buck Louis, G. M., 2017, In: Human Reproduction. 32, 3, p. 499-504

    Research output: Contribution to journal › Comment/debate › Research

  16. Published

    Sweat secretion rates in growth hormone disorders

    Sneppen, S. B., Main, Katharina Maria, Juul, Anders, Pedersen, L. M., Kristensen, L. O., Skakkebæk, Niels Erik & Feldt-Rasmussen, Ulla, 2000, In: Clinical Endocrinology. 53, 5, p. 601-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly

    Sneppen, S. B., Lange, M. W., Pedersen, L. M., Kristensen L, L. Ø., Main, Katharina Maria, Juul, Anders, Skakkebæk, Niels Erik & Feldt-Rasmussen, Ulla, 2001, In: Growth Hormone & I G F Research. 11, 6, p. 384-91 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Leydig cell clustering and Reinke crystal distribution in relation to hormonal function in adult patients with testicular dysgenesis syndrome (TDS) including cryptorchidism

    Soerensen, R. R., Johannsen, T. H., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., Oct 2016, In: Hormones. 15, 4, p. 518-526 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours

    Sonne, Si Brask, Hoei-Hansen, C. E., Nielsen, J. E., Herlihy, A. S., Andersson, A., Almstrup, Kristian, Daugaard, G., Skakkebæk, Niels Erik, Leffers, H., Rajpert-De Meyts, E., Sonne, S. B., Hoei-Hansen, C. E., Nielsen, J. E., Herlihy, A. S., Andersson, A., Almstrup, K., Daugaard, G., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2006, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 114, 7-8, p. 549-58 10 p.

    Research output: Contribution to journal › Journal article › Research

  20. Published

    Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte

    Sonne, Si Brask, Almstrup, Kristian, Dalgaard, M., Juncker, A. S., Edsgard, D., Ruban, L., Harrison, N. J., Schwager, C., Abdollahi, A., Huber, P. E., Brunak, Søren, Gjerdrum, L. M., Moore, H. D., Andrews, P. W., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 15 Jun 2009, In: Current Cancer Research. 69, 12, p. 5241-50 10 p.

    Research output: Contribution to journal › Journal article › Research

  21. Published

    Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours

    Sonne, Si Brask, Herlihy, A. S., Hoei-Hansen, C. E., Nielsen, J. E., Almstrup, Kristian, Skakkebæk, Niels Erik, Marks, A., Leffers, H. & Rajpert-De Meyts, E., 2006, In: Virchows Archiv. 449, 2, p. 200-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Testicular dysgenesis syndrome and the origin of carcinoma in situ testis

    Sonne, Si Brask, Kristensen, D. M., Novotny, G. W., Olesen, I. A., Nielsen, J. E., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 2008, In: International Journal of Andrology. 31, 2, p. 275-87 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Do environmental factors play a role in the aetiology of carcinoma in situ testis and the testicular dysgenesis syndrome?

    Sonne, Si Brask, Hoei-Hansen, C. E., Fisher, J. S., Leffers, H., Rajpert-de Meyts, E. & Skakkebæk, Niels Erik, 2004, In: Verhandlungen der Deutschen Gesellschaft fur Pathologie. 88, p. 144-51 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Testicular function in young men in long-term remission after treatment for the early stages of Hodgkin's disease

    Specht, Lena, Geisler, C., Hansen, M. M. & Skakkebæk, Niels Erik, 1 Oct 1984, In: Scandinavian journal of haematology. 33, 4, p. 356-62 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Serum sex hormone-binding globulin levels in healthy children and girls with precocious puberty before and during gonadotropin-releasing hormone agonist treatment

    Sørensen, K., Andersson, A. M., Skakkebæk, Niels Erik & Juul, Anders, 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 8, p. 3189-96 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Quantification of the Leydig cell compartment in testicular biopsies and association with biochemical Leydig cell dysfunction in testicular cancer survivors

    Tarsitano, M. G., Bandak, M., Jørgensen, N., Skakkebæk, Niels Erik, Juul, Anders, Lenzi, A., Daugaard, G. & Rajpert-De Meyts, E., 2018, In: Andrology. 6, 5, p. 748-755 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Hypothesis: Metformin is a potential reproductive toxicant

    Tavlo, M., Skakkebæk, Niels Erik, Mathiesen, Elisabeth, Kristensen, D. M., Kjær, Kurt H., Andersson, A. & Lindahl-Jacobsen, R., 2022, In: Frontiers in Endocrinology. 13, 8 p., 1000872.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years

    Teilmann, Grete Katrine, Petersen, Jørgen Holm, Gormsen, M., Damgaard, K., Skakkebæk, Niels Erik, Jensen, T. K., Teilmann, Grete Katrine, Petersen, J. H., Gormsen, M., Damgaard, K., Skakkebæk, Niels Erik & Jensen, T. K., 1 Jan 2009, In: Hormone Research. 72, 4, p. 236-46 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries

    Teilmann, Grete Katrine, Pedersen, C., Jensen, T. K., Skakkebæk, Niels Erik & Juul, Anders, 2005, In: Pediatrics. 116, 6, p. 1323-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Putative effects of endocrine disrupters on pubertal development in the human

    Teilmann, Grete Katrine, Juul, Anders, Skakkebæk, Niels Erik & Toppari, J., 2002, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 16, 1, p. 105-21 17 p.

    Research output: Contribution to journal › Journal article › Research

  31. Published

    Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up

    Thorup, Jørgen Mogens, Mauritzen, K. & Skakkebæk, Niels Erik, 1987, In: European Journal of Pediatrics. 146 Suppl 2, p. S40-1

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Re: The true incidence of cryptorchidism in Denmark: D. Cortes, E. M. Kjellberg, M. Breddam and J. Thorup, J Urol 2008; 179: 314-318

    Thorup, Jørgen Mogens, Cortes, Dina, Main, Katharina Maria, Skakkebæk, Niels Erik & Toppari, J., Feb 2009, In: The Journal of Urology. 181, 2, p. 922-4 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Prenatal pesticide exposure and PON1 genotype associated with adolescent body fat distribution evaluated by dual X-ray absorptiometry (DXA)

    Tinggaard, J., Wohlfahrt-Veje, C., Husby, S., Christiansen, L., Skakkebæk, Niels Erik, Jensen, T. K., Grandjean, P., Main, Katharina Maria & Andersen, H. R., Jul 2016, In: Andrology. 4, 4, p. 735-744 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring: A Registry-Based Case-Control Study

    Togawa, K., Le Cornet, C., Feychting, M., Tynes, T., Pukkala, E., Hansen, J., Olsson, A., Dalton, S. O., Nordby, K., Uuksulainen, S., Wiebert, P., Woldbæk, T., Skakkebæk, Niels Erik, Fervers, B. & Schüz, J., Oct 2016, In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 25, 10, p. 1426-1434 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Male reproductive health and environmental xenoestrogens

    Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jégou, B., Jensen, T. K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J. A., Meyer, O., Müller, J., Rajpert-De Meyts, E., Scheike, T., Sharpe, R., Sumpter, J. & Skakkebæk, Niels Erik, 1 Aug 1996, In: Environmental Health Perspectives. 104 Suppl 4, p. 741-803 63 p.

    Research output: Contribution to journal › Journal article › Research

  36. Published

    Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection

    Toppari, J., Virtanen, H. E., Main, Katharina Maria & Skakkebæk, Niels Erik, 1 Oct 2010, In: Birth Defects Research. Part A: Clinical and Molecular Teratology. 88, 10, p. 910-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Possible developmental early effects of endocrine disrupters on child health

    Toppari, J., Adamsson, A., Boas, M., Juul, Anders, Main, Katharina Maria, Skakkebæk, Niels Erik & Virtanen, H., 2012, WHO report 2012. p. 1-83

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  38. Published

    Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis

    Trasande, L., Zoeller, R. T., Hass, U., Kortenkamp, A., Grandjean, P., Myers, J. P., DiGangi, J., Hunt, P. M., Rudel, R., Sathyanarayana, S., Bellanger, M., Hauser, R., Legler, J., Skakkebæk, Niels Erik & Heindel, J. J., Jul 2016, In: Andrology. 4, 4, p. 565-572 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias

    Tysman, M., Toppari, J., Main, Katharina Maria, Adamsson, A., Wohlfahrt-Veje, C., Antignac, J., Le Bizec, B., Löyttyniemi, E., Skakkebæk, Niels Erik & Virtanen, H. E., 2023, In: Chemosphere. 313, 8 p., 137343.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Smaller genitals at school age in boys whose mothers were exposed to non-persistent pesticides in early pregnancy

    Veje, C. W., Andersen, H. R., Jensen, T. K., Grandjean, P., Skakkebæk, Niels Erik & Main, Katharina Maria, 2012, In: International Journal of Andrology. 35, 3, p. 265-72 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Early breast development in girls after prenatal exposure to non-persistent pesticides

    Veje, C. W., Andersen, H. R., Schmidt, I. M., Aksglaede, L., Sørensen, K., Juul, Anders, Jensen, T. K., Grandjean, P., Skakkebæk, Niels Erik & Main, Katharina Maria, 2012, In: International Journal of Andrology. 35, 3, p. 273-82

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta

    Virtanen, H. E., Koskenniemi, J. J., Sundqvist, E., Main, Katharina Maria, Kiviranta, H., Tuomisto, J. T., Tuomisto, J., Viluksela, M., Vartiainen, T., Skakkebæk, Niels Erik & Toppari, J., 2012, In: International Journal of Andrology. 35, 3, p. 283-93 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Development and descent of the testis in relation to cryptorchidism

    Virtanen, H. E., Cortes, Dina, Rajpert-De Meyts, E., Ritzén, E. M., Nordenskjöld, A., Skakkebæk, Niels Erik & Toppari, J., 1 May 2007, In: Acta Paediatrica. 96, 5, p. 622-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Nervous system drugs taken by future fathers and birth defects in offspring: a prospective registry-based cohort study

    Wensink, M., Lu, Y., Tian, L., Jensen, T. K., Skakkebæk, Niels Erik, Lindahl-Jacobsen, R. & Eisenberg, M., 2022, In: BMJ Open. 12, 3, 8 p., e053946.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study

    Wensink, M. J., Lu, Y., Tian, L., Shaw, G. M., Rizzi, S., Jensen, T. K., Mathiesen, Elisabeth, Skakkebæk, Niels Erik, Lindahl-Jacobsen, R. & Eisenberg, M. L., 2022, In: Annals of Internal Medicine. 175, 5, p. 665-673 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells

    Winge, S. B., Dalgaard, M. D., Belling, K. G., Jensen, J. M., Nielsen, J. E., Aksglaede, L., Schierup, M. H., Brunak, Søren, Skakkebæk, Niels Erik, Juul, Anders, Rajpert-De Meyts, E. & Almstrup, Kristian, 2018, In: Cell Death & Disease. 9, 6, 14 p., 586.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Testicular dysgenesis syndrome: foetal origin of adult reproductive problems

    Wohlfahrt-Veje, C., Main, Katharina Maria & Skakkebæk, Niels Erik, 2009, In: Clinical Endocrinology. 71, 4, p. 459-65 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Polychlorinated dibenzo-p-dioxins, furans, and biphenyls (PCDDs/PCDFs and PCBs) in breast milk and early childhood growth and IGF1

    Wohlfahrt-Veje, C., Audouze, K., Brunak, Søren, Antignac, J. P., le Bizec, B., Juul, Anders, Skakkebæk, Niels Erik & Main, Katharina Maria, 2014, In: Reproduction. 147, 4, p. 391-399 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Acquired cryptorchidism is frequent in infancy and childhood

    Wohlfahrt-Veje, C., Boisen, K. A., Boas, M., Damgaard, I. N., Kai, C. M., Schmidt, I. M., Chellakooty, M., Suomi, A., Toppari, J., Skakkebæk, Niels Erik & Main, Katharina Maria, 2009, In: International Journal of Andrology. 32, 4, p. 423-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Pubertal Onset in Boys and Girls Is Influenced by Pubertal Timing of Both Parents

    Wohlfahrt-Veje, C., Mouritsen, A., Hagen, C. P., Tinggaard, J., Mieritz, M. G., Boas, M., Petersen, Jørgen Holm, Skakkebæk, Niels Erik & Main, Katharina Maria, Jul 2016, In: The Journal of Clinical Endocrinology & Metabolism. 101, 7, p. 2667–2674 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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