Development and descent of the testis in relation to cryptorchidism
Research output: Contribution to journal › Journal article › Research › peer-review
The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.
| Original language | English |
|---|---|
| Journal | Acta Paediatrica |
| Volume | 96 |
| Issue number | 5 |
| Pages (from-to) | 622-7 |
| Number of pages | 6 |
| ISSN | 0803-5253 |
| DOIs | |
| Publication status | Published - 1 May 2007 |
- Animals, Cell Differentiation, Child, Cryptorchidism, Humans, Infant, Insulin, Leydig Cells, Male, Models, Animal, Proteins, Testis
Research areas
ID: 34345351