Association Between Use of Marijuana and Male Reproductive Hormones and Semen Quality: A Study Among 1,215 Healthy Young Men
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Association Between Use of Marijuana and Male Reproductive Hormones and Semen Quality : A Study Among 1,215 Healthy Young Men. / Gundersen, Tina Djernis; Jørgensen, Niels; Andersson, Anna-Maria; Bang, Anne Kirstine; Nordkap, Loa; Skakkebæk, Niels E; Priskorn, Lærke; Juul, Anders; Jensen, Tina Kold.
In: American Journal of Epidemiology, Vol. 182, No. 6, 2015, p. 473-81.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Association Between Use of Marijuana and Male Reproductive Hormones and Semen Quality
T2 - A Study Among 1,215 Healthy Young Men
AU - Gundersen, Tina Djernis
AU - Jørgensen, Niels
AU - Andersson, Anna-Maria
AU - Bang, Anne Kirstine
AU - Nordkap, Loa
AU - Skakkebæk, Niels E
AU - Priskorn, Lærke
AU - Juul, Anders
AU - Jensen, Tina Kold
N1 - © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2015
Y1 - 2015
N2 - A total of 1,215 young Danish men aged 18-28 years were recruited between 2008 and 2012 when they attended a compulsory medical examination to determine their fitness for military service. The participants delivered a semen sample, had a blood sample drawn, and underwent a physical examination. They responded to questionnaires including information on marijuana and recreational drug use during the past 3 months (no use, use once per week or less, or use more than once per week). A total of 45% had smoked marijuana within the last 3 months. Regular marijuana smoking more than once per week was associated with a 28% (95% confidence interval (CI): -48, -1) lower sperm concentration and a 29% (95% CI: -46, -1) lower total sperm count after adjustment for confounders. The combined use of marijuana more than once per week and other recreational drugs reduced the sperm concentration by 52% (95% CI: -68, -27) and total sperm count by 55% (95% CI: -71, -31). Marijuana smokers had higher levels of testosterone within the same range as cigarette smokers. Our findings are of public interest as marijuana use is common and may be contributing to recent reports of poor semen quality.
AB - A total of 1,215 young Danish men aged 18-28 years were recruited between 2008 and 2012 when they attended a compulsory medical examination to determine their fitness for military service. The participants delivered a semen sample, had a blood sample drawn, and underwent a physical examination. They responded to questionnaires including information on marijuana and recreational drug use during the past 3 months (no use, use once per week or less, or use more than once per week). A total of 45% had smoked marijuana within the last 3 months. Regular marijuana smoking more than once per week was associated with a 28% (95% confidence interval (CI): -48, -1) lower sperm concentration and a 29% (95% CI: -46, -1) lower total sperm count after adjustment for confounders. The combined use of marijuana more than once per week and other recreational drugs reduced the sperm concentration by 52% (95% CI: -68, -27) and total sperm count by 55% (95% CI: -71, -31). Marijuana smokers had higher levels of testosterone within the same range as cigarette smokers. Our findings are of public interest as marijuana use is common and may be contributing to recent reports of poor semen quality.
KW - Adolescent
KW - Adult
KW - Cross-Sectional Studies
KW - Denmark
KW - Follow-Up Studies
KW - Healthy Volunteers
KW - Humans
KW - Incidence
KW - Male
KW - Marijuana Abuse
KW - Reproductive Health
KW - Retrospective Studies
KW - Semen Analysis
KW - Sperm Count
KW - Testosterone
KW - Young Adult
U2 - 10.1093/aje/kwv135
DO - 10.1093/aje/kwv135
M3 - Journal article
C2 - 26283092
VL - 182
SP - 473
EP - 481
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 6
ER -
ID: 162253783