Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women
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Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women. / Antignac, J P; Main, K M; Virtanen, H E; Boquien, C Y; Marchand, P; Venisseau, A; Guiffard, I; Bichon, E; Wohlfahrt-Veje, C; Legrand, Sara-Ann; Boscher, C; Skakkebæk, Niels E; Toppari, J; Le Bizec, B.
In: Environmental Pollution, Vol. 218, 11.2016, p. 728-738.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women
AU - Antignac, J P
AU - Main, K M
AU - Virtanen, H E
AU - Boquien, C Y
AU - Marchand, P
AU - Venisseau, A
AU - Guiffard, I
AU - Bichon, E
AU - Wohlfahrt-Veje, C
AU - Legrand, Sara-Ann
AU - Boscher, C
AU - Skakkebæk, Niels E
AU - Toppari, J
AU - Le Bizec, B
N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.
PY - 2016/11
Y1 - 2016/11
N2 - The present study compares concentrations and chemical profiles of an extended range of persistent organic pollutants (dioxins, polychlorobiphenyls, brominated flame retardants and organochlorine pesticides) in breast milk samples from French (n = 96), Danish (n = 438) and Finnish (n = 22) women. Median exposure levels observed in French women (WHO-TEQ2005 PCDD/F = 6.1 pg/g l.w., WHO-TEQ2005 dl-PCB = 4.3 pg/g l.w., sum of 6 ndl-PCB = 85.2 ng/g l.w., sum of 7 i-PBDE = 1.5 ng/g l.w.) appeared overall lower than in Danish and Finnish women for all examined POPs, except for α-HBCD (2-fold higher level at 0.6 ng/g l.w.). Furthermore, the observed exposure levels of dioxins and PCBs were higher in Danish women (WHO-TEQ2005 PCDD/F = 13.2 pg/g l.w., WHO-TEQ2005 dl-PCB = 6.6 pg/g l.w., sum of 6 ndl-PCB = 162.8 ng/g l.w.) compared to Finnish women (WHO-TEQ2005 PCDD/F = 9.0 pg/g l.w., WHO-TEQ2005 dl-PCB = 4.6 pg/g l.w., sum of 6 ndl-PCB = 104.0 ng/g l.w.), whereas the concentrations of PBDEs were similar for Danish and Finnish women (sum of 7 i-PBDE = 4.9 and 5.2 ng/g l.w. respectively). The organochlorine (OC) pesticide contamination profile, determined in a subset of French samples, was dominated by p,p'-DDE (56.6%), followed by β-HCH (14.2%), HCB (9.7%) and dieldrin (5.2%), while other compounds were only minor contributors (<5%). The three countries appeared to be discriminated by the observed contamination patterns of the PCDD/F versus PCB, and the 1,2,3,6,7,8-HxCDD versus 1,2,3,4,7,8-HxCDD ratios, in addition to the relative contributions of specific congeners to the contamination profile (PCBs #118 and #156, PBDEs #28, #47, #99 and #153). In conclusion, unique chemical signatures were observed for each country on the basis of some POP congeners. Future biomonitoring studies will need to consider the high variability of individual exposure profiles in relation to multiple exposure sources but also physiological and metabolic differences.
AB - The present study compares concentrations and chemical profiles of an extended range of persistent organic pollutants (dioxins, polychlorobiphenyls, brominated flame retardants and organochlorine pesticides) in breast milk samples from French (n = 96), Danish (n = 438) and Finnish (n = 22) women. Median exposure levels observed in French women (WHO-TEQ2005 PCDD/F = 6.1 pg/g l.w., WHO-TEQ2005 dl-PCB = 4.3 pg/g l.w., sum of 6 ndl-PCB = 85.2 ng/g l.w., sum of 7 i-PBDE = 1.5 ng/g l.w.) appeared overall lower than in Danish and Finnish women for all examined POPs, except for α-HBCD (2-fold higher level at 0.6 ng/g l.w.). Furthermore, the observed exposure levels of dioxins and PCBs were higher in Danish women (WHO-TEQ2005 PCDD/F = 13.2 pg/g l.w., WHO-TEQ2005 dl-PCB = 6.6 pg/g l.w., sum of 6 ndl-PCB = 162.8 ng/g l.w.) compared to Finnish women (WHO-TEQ2005 PCDD/F = 9.0 pg/g l.w., WHO-TEQ2005 dl-PCB = 4.6 pg/g l.w., sum of 6 ndl-PCB = 104.0 ng/g l.w.), whereas the concentrations of PBDEs were similar for Danish and Finnish women (sum of 7 i-PBDE = 4.9 and 5.2 ng/g l.w. respectively). The organochlorine (OC) pesticide contamination profile, determined in a subset of French samples, was dominated by p,p'-DDE (56.6%), followed by β-HCH (14.2%), HCB (9.7%) and dieldrin (5.2%), while other compounds were only minor contributors (<5%). The three countries appeared to be discriminated by the observed contamination patterns of the PCDD/F versus PCB, and the 1,2,3,6,7,8-HxCDD versus 1,2,3,4,7,8-HxCDD ratios, in addition to the relative contributions of specific congeners to the contamination profile (PCBs #118 and #156, PBDEs #28, #47, #99 and #153). In conclusion, unique chemical signatures were observed for each country on the basis of some POP congeners. Future biomonitoring studies will need to consider the high variability of individual exposure profiles in relation to multiple exposure sources but also physiological and metabolic differences.
KW - Adult
KW - Animals
KW - Denmark
KW - Environmental Monitoring
KW - Environmental Pollutants
KW - Female
KW - Finland
KW - Flame Retardants
KW - France
KW - Halogenated Diphenyl Ethers
KW - Humans
KW - Hydrocarbons, Chlorinated
KW - Milk, Human
KW - Pesticides
KW - Polychlorinated Biphenyls
KW - Journal Article
U2 - 10.1016/j.envpol.2016.07.069
DO - 10.1016/j.envpol.2016.07.069
M3 - Journal article
C2 - 27521295
VL - 218
SP - 728
EP - 738
JO - Environmental Pollution
JF - Environmental Pollution
SN - 0269-7491
ER -
ID: 176452144