Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy
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Germ cell neoplasia in situ (GCNIS) : evolution of the current nomenclature for testicular pre-invasive germ cell malignancy. / Berney, Daniel M; Looijenga, Leendert H J; Idrees, Muhammad; Oosterhuis, J Wolter; Rajpert-De Meyts, Ewa; Ulbright, Thomas M; Skakkebaek, Niels E.
In: Histopathology, Vol. 69, No. 1, 07.2016, p. 7-10.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Germ cell neoplasia in situ (GCNIS)
T2 - evolution of the current nomenclature for testicular pre-invasive germ cell malignancy
AU - Berney, Daniel M
AU - Looijenga, Leendert H J
AU - Idrees, Muhammad
AU - Oosterhuis, J Wolter
AU - Rajpert-De Meyts, Ewa
AU - Ulbright, Thomas M
AU - Skakkebaek, Niels E
N1 - © 2016 John Wiley & Sons Ltd.
PY - 2016/7
Y1 - 2016/7
N2 - The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity and disagreement on its name. Initially termed 'carcinoma in situ' (CIS), it has also been known as 'intratubular germ cell neoplasia, unclassified' (IGCNU) and 'testicular intraepithelial neoplasia' (TIN). In this paper, we review the history of discovery and controversy concerning these names and introduce the reasoning for uniting behind a new name, endorsed unanimously at the World Health Organization (WHO) consensus classification 2016: germ cell neoplasia in situ (GCNIS).
AB - The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity and disagreement on its name. Initially termed 'carcinoma in situ' (CIS), it has also been known as 'intratubular germ cell neoplasia, unclassified' (IGCNU) and 'testicular intraepithelial neoplasia' (TIN). In this paper, we review the history of discovery and controversy concerning these names and introduce the reasoning for uniting behind a new name, endorsed unanimously at the World Health Organization (WHO) consensus classification 2016: germ cell neoplasia in situ (GCNIS).
KW - Journal Article
KW - Review
U2 - 10.1111/his.12958
DO - 10.1111/his.12958
M3 - Review
C2 - 26918959
VL - 69
SP - 7
EP - 10
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 1
ER -
ID: 176830018