Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up
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Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up. / Thorup, Jørgen Mogens; Mauritzen, K; Skakkebaek, N E.
In: European Journal of Pediatrics, Vol. 146 Suppl 2, 1987, p. S40-1.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up
AU - Thorup, Jørgen Mogens
AU - Mauritzen, K
AU - Skakkebaek, N E
PY - 1987
Y1 - 1987
N2 - The effect of intranasal LH-RH on cryptorchidism was investigated in 45 prepubertal boys with 68 undescended testes. A daily dose of 1.2 mg LH-RH was given for 4 weeks. A total of 16 testes (24%) descended. Follow-up examination 5 years later showed that relapse had occurred in two cases. Fifty-two testes did not descend during the LH-RH treatment. However, seven of these testes descended spontaneously during puberty. So far surgical treatment has been carried out in 39 of the remaining 45 testes. Anatomical anomalies (ectopic position of the testis, open processus vaginalis, abnormal epididymis) explained the failure of LH-RH to cause descent in the majority of the surgically treated cases.
AB - The effect of intranasal LH-RH on cryptorchidism was investigated in 45 prepubertal boys with 68 undescended testes. A daily dose of 1.2 mg LH-RH was given for 4 weeks. A total of 16 testes (24%) descended. Follow-up examination 5 years later showed that relapse had occurred in two cases. Fifty-two testes did not descend during the LH-RH treatment. However, seven of these testes descended spontaneously during puberty. So far surgical treatment has been carried out in 39 of the remaining 45 testes. Anatomical anomalies (ectopic position of the testis, open processus vaginalis, abnormal epididymis) explained the failure of LH-RH to cause descent in the majority of the surgically treated cases.
KW - Administration, Intranasal
KW - Child
KW - Clinical Trials as Topic
KW - Cryptorchidism
KW - Follow-Up Studies
KW - Gonadotropin-Releasing Hormone
KW - Humans
KW - Male
KW - Time Factors
M3 - Journal article
C2 - 2891520
VL - 146 Suppl 2
SP - S40-1
JO - Acta Paediatrica Hungarica
JF - Acta Paediatrica Hungarica
SN - 0340-6199
ER -
ID: 47629453