Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer
Research output: Contribution to journal › Comment/debate › Research
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Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer. / Smarr, Melissa M; Sapra, Katherine J; Gemmill, Alison; Kahn, Linda G; Wise, Lauren A; Lynch, Courtney D; Factor-Litvak, Pam; Mumford, Sunni L; Skakkebaek, Niels E; Slama, Rémy; Lobdell, Danelle T; Stanford, Joseph B; Jensen, Tina Kold; Boyle, Elizabeth Heger; Eisenberg, Michael L; Turek, Paul J; Sundaram, Rajeshwari; Thoma, Marie E; Buck Louis, Germaine M.
In: Human Reproduction, Vol. 32, No. 3, 2017, p. 499-504.Research output: Contribution to journal › Comment/debate › Research
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TY - JOUR
T1 - Is human fecundity changing?
T2 - A discussion of research and data gaps precluding us from having an answer
AU - Smarr, Melissa M
AU - Sapra, Katherine J
AU - Gemmill, Alison
AU - Kahn, Linda G
AU - Wise, Lauren A
AU - Lynch, Courtney D
AU - Factor-Litvak, Pam
AU - Mumford, Sunni L
AU - Skakkebaek, Niels E
AU - Slama, Rémy
AU - Lobdell, Danelle T
AU - Stanford, Joseph B
AU - Jensen, Tina Kold
AU - Boyle, Elizabeth Heger
AU - Eisenberg, Michael L
AU - Turek, Paul J
AU - Sundaram, Rajeshwari
AU - Thoma, Marie E
AU - Buck Louis, Germaine M
N1 - Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PY - 2017
Y1 - 2017
N2 - Fecundity, the biologic capacity to reproduce, is essential for the health of individuals and is, therefore, fundamental for understanding human health at the population level. Given the absence of a population (bio)marker, fecundity is assessed indirectly by various individual-based (e.g. semen quality, ovulation) or couple-based (e.g. time-to-pregnancy) endpoints. Population monitoring of fecundity is challenging, and often defaults to relying on rates of births (fertility) or adverse outcomes such as genitourinary malformations and reproductive site cancers. In light of reported declines in semen quality and fertility rates in some global regions among other changes, the question as to whether human fecundity is changing needs investigation. We review existing data and novel methodological approaches aimed at answering this question from a transdisciplinary perspective. The existing literature is insufficient for answering this question; we provide an overview of currently available resources and novel methods suitable for delineating temporal patterns in human fecundity in future research.
AB - Fecundity, the biologic capacity to reproduce, is essential for the health of individuals and is, therefore, fundamental for understanding human health at the population level. Given the absence of a population (bio)marker, fecundity is assessed indirectly by various individual-based (e.g. semen quality, ovulation) or couple-based (e.g. time-to-pregnancy) endpoints. Population monitoring of fecundity is challenging, and often defaults to relying on rates of births (fertility) or adverse outcomes such as genitourinary malformations and reproductive site cancers. In light of reported declines in semen quality and fertility rates in some global regions among other changes, the question as to whether human fecundity is changing needs investigation. We review existing data and novel methodological approaches aimed at answering this question from a transdisciplinary perspective. The existing literature is insufficient for answering this question; we provide an overview of currently available resources and novel methods suitable for delineating temporal patterns in human fecundity in future research.
KW - Birth Rate
KW - Female
KW - Fertility/physiology
KW - Humans
KW - Male
KW - Pregnancy
KW - Reproduction/physiology
KW - Time-to-Pregnancy
U2 - 10.1093/humrep/dew361
DO - 10.1093/humrep/dew361
M3 - Comment/debate
C2 - 28137753
VL - 32
SP - 499
EP - 504
JO - Human Reproduction
JF - Human Reproduction
SN - 0268-1161
IS - 3
ER -
ID: 193509803