Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. / Andersen, Helle R; Veje, Christine Wohlfahrt; Dalgård, Christine; Christiansen, Lene Trelle; Main, Katharina M; Nellemann, Christine Lydia; Murata, Katsuyuki; Jensen, Tina K; Skakkebæk, Niels E; Grandjean, Philippe.

In: P L o S One, Vol. 7, No. 5, 2012, p. e36830.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Andersen, HR, Veje, CW, Dalgård, C, Christiansen, LT, Main, KM, Nellemann, CL, Murata, K, Jensen, TK, Skakkebæk, NE & Grandjean, P 2012, 'Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age', P L o S One, vol. 7, no. 5, pp. e36830. https://doi.org/10.1371/journal.pone.0036830

APA

Andersen, H. R., Veje, C. W., Dalgård, C., Christiansen, L. T., Main, K. M., Nellemann, C. L., Murata, K., Jensen, T. K., Skakkebæk, N. E., & Grandjean, P. (2012). Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. P L o S One, 7(5), e36830. https://doi.org/10.1371/journal.pone.0036830

Vancouver

Andersen HR, Veje CW, Dalgård C, Christiansen LT, Main KM, Nellemann CL et al. Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. P L o S One. 2012;7(5):e36830. https://doi.org/10.1371/journal.pone.0036830

Author

Andersen, Helle R ; Veje, Christine Wohlfahrt ; Dalgård, Christine ; Christiansen, Lene Trelle ; Main, Katharina M ; Nellemann, Christine Lydia ; Murata, Katsuyuki ; Jensen, Tina K ; Skakkebæk, Niels E ; Grandjean, Philippe. / Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. In: P L o S One. 2012 ; Vol. 7, No. 5. pp. e36830.

Bibtex

@article{cde29c4057ac4f34b2985a088c460fae,
title = "Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age",
abstract = "Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides.",
author = "Andersen, {Helle R} and Veje, {Christine Wohlfahrt} and Christine Dalg{\aa}rd and Christiansen, {Lene Trelle} and Main, {Katharina M} and Nellemann, {Christine Lydia} and Katsuyuki Murata and Jensen, {Tina K} and Skakkeb{\ae}k, {Niels E} and Philippe Grandjean",
year = "2012",
doi = "10.1371/journal.pone.0036830",
language = "English",
volume = "7",
pages = "e36830",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

RIS

TY - JOUR

T1 - Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age

AU - Andersen, Helle R

AU - Veje, Christine Wohlfahrt

AU - Dalgård, Christine

AU - Christiansen, Lene Trelle

AU - Main, Katharina M

AU - Nellemann, Christine Lydia

AU - Murata, Katsuyuki

AU - Jensen, Tina K

AU - Skakkebæk, Niels E

AU - Grandjean, Philippe

PY - 2012

Y1 - 2012

N2 - Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides.

AB - Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides.

U2 - 10.1371/journal.pone.0036830

DO - 10.1371/journal.pone.0036830

M3 - Journal article

C2 - 22615820

VL - 7

SP - e36830

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 5

ER -

ID: 40178588