Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring: A Registry-Based Case-Control Study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring : A Registry-Based Case-Control Study. / Togawa, Kayo; Le Cornet, Charlotte; Feychting, Maria; Tynes, Tore; Pukkala, Eero; Hansen, Johnnie; Olsson, Ann; Dalton, Susanne Oksbjerg; Nordby, Karl-Christian; Uuksulainen, Sanni; Wiebert, Pernilla; Woldbæk, Torill; Skakkebæk, Niels E; Fervers, Béatrice; Schüz, Joachim.

In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 25, No. 10, 10.2016, p. 1426-1434.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Togawa, K, Le Cornet, C, Feychting, M, Tynes, T, Pukkala, E, Hansen, J, Olsson, A, Dalton, SO, Nordby, K-C, Uuksulainen, S, Wiebert, P, Woldbæk, T, Skakkebæk, NE, Fervers, B & Schüz, J 2016, 'Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring: A Registry-Based Case-Control Study', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol. 25, no. 10, pp. 1426-1434. https://doi.org/10.1158/1055-9965.EPI-16-0328

APA

Togawa, K., Le Cornet, C., Feychting, M., Tynes, T., Pukkala, E., Hansen, J., Olsson, A., Dalton, S. O., Nordby, K-C., Uuksulainen, S., Wiebert, P., Woldbæk, T., Skakkebæk, N. E., Fervers, B., & Schüz, J. (2016). Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring: A Registry-Based Case-Control Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 25(10), 1426-1434. https://doi.org/10.1158/1055-9965.EPI-16-0328

Vancouver

Togawa K, Le Cornet C, Feychting M, Tynes T, Pukkala E, Hansen J et al. Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring: A Registry-Based Case-Control Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2016 Oct;25(10):1426-1434. https://doi.org/10.1158/1055-9965.EPI-16-0328

Author

Togawa, Kayo ; Le Cornet, Charlotte ; Feychting, Maria ; Tynes, Tore ; Pukkala, Eero ; Hansen, Johnnie ; Olsson, Ann ; Dalton, Susanne Oksbjerg ; Nordby, Karl-Christian ; Uuksulainen, Sanni ; Wiebert, Pernilla ; Woldbæk, Torill ; Skakkebæk, Niels E ; Fervers, Béatrice ; Schüz, Joachim. / Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring : A Registry-Based Case-Control Study. In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2016 ; Vol. 25, No. 10. pp. 1426-1434.

Bibtex

@article{ece7a780dc1c48dcab6eede5237ff365,
title = "Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring: A Registry-Based Case-Control Study",
abstract = "BACKGROUND: Data are scarce on the association between prenatal/preconception environmental exposure and testicular germ cell tumor (TGCT) in offspring. We examined parental occupational exposures to heavy metals and welding fumes in relation to TGCT in offspring in a registry-based case-control study (NORD-TEST Study).METHODS: We identified TGCT cases diagnosed at ages 14-49 years in Finland (1988-2012), Norway (1978-2010), and Sweden (1979-2011) through nationwide cancer registries. These cases were individually matched by country and year of birth to controls selected from population registries. Information on parental occupations was retrieved from censuses. From this, we estimated prenatal/preconception exposures of chromium, iron, nickel, lead, and welding fumes (all three countries), and cadmium (Finland only) for each parent using job-exposure matrices specifying prevalence (P) and mean exposure level (L). Exposure indices were calculated as a product of P and L (P × L), and exposure categories were based on P × L or different combinations of P and L.RESULTS: The study comprised 8,112 cases and 26,264 controls. We observed no statistically significant TGCT risk associated with presence of heavy metals/welding fumes (P × L > 0) and no dose-response relationship (Ptrend ≥ 0.32). A statistically significant elevated TGCT risk was found in paternal exposure category where both P and L of chromium were high (vs. no chromium; OR = 1.37, 95% confidence interval; 1.05-1.79).CONCLUSIONS: Our study provides little evidence of associations between parental exposures to heavy metals/welding fumes and TGCT in offspring with the potential exception of high paternal chromium exposure.IMPACT: Further research on paternal chromium exposure is warranted. Cancer Epidemiol Biomarkers Prev; 25(10); 1426-34. {\textcopyright}2016 AACR.",
author = "Kayo Togawa and {Le Cornet}, Charlotte and Maria Feychting and Tore Tynes and Eero Pukkala and Johnnie Hansen and Ann Olsson and Dalton, {Susanne Oksbjerg} and Karl-Christian Nordby and Sanni Uuksulainen and Pernilla Wiebert and Torill Woldb{\ae}k and Skakkeb{\ae}k, {Niels E} and B{\'e}atrice Fervers and Joachim Sch{\"u}z",
note = "{\textcopyright}2016 American Association for Cancer Research.",
year = "2016",
month = oct,
doi = "10.1158/1055-9965.EPI-16-0328",
language = "English",
volume = "25",
pages = "1426--1434",
journal = "Cancer Epidemiology, Biomarkers & Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research (A A C R)",
number = "10",

}

RIS

TY - JOUR

T1 - Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring

T2 - A Registry-Based Case-Control Study

AU - Togawa, Kayo

AU - Le Cornet, Charlotte

AU - Feychting, Maria

AU - Tynes, Tore

AU - Pukkala, Eero

AU - Hansen, Johnnie

AU - Olsson, Ann

AU - Dalton, Susanne Oksbjerg

AU - Nordby, Karl-Christian

AU - Uuksulainen, Sanni

AU - Wiebert, Pernilla

AU - Woldbæk, Torill

AU - Skakkebæk, Niels E

AU - Fervers, Béatrice

AU - Schüz, Joachim

N1 - ©2016 American Association for Cancer Research.

PY - 2016/10

Y1 - 2016/10

N2 - BACKGROUND: Data are scarce on the association between prenatal/preconception environmental exposure and testicular germ cell tumor (TGCT) in offspring. We examined parental occupational exposures to heavy metals and welding fumes in relation to TGCT in offspring in a registry-based case-control study (NORD-TEST Study).METHODS: We identified TGCT cases diagnosed at ages 14-49 years in Finland (1988-2012), Norway (1978-2010), and Sweden (1979-2011) through nationwide cancer registries. These cases were individually matched by country and year of birth to controls selected from population registries. Information on parental occupations was retrieved from censuses. From this, we estimated prenatal/preconception exposures of chromium, iron, nickel, lead, and welding fumes (all three countries), and cadmium (Finland only) for each parent using job-exposure matrices specifying prevalence (P) and mean exposure level (L). Exposure indices were calculated as a product of P and L (P × L), and exposure categories were based on P × L or different combinations of P and L.RESULTS: The study comprised 8,112 cases and 26,264 controls. We observed no statistically significant TGCT risk associated with presence of heavy metals/welding fumes (P × L > 0) and no dose-response relationship (Ptrend ≥ 0.32). A statistically significant elevated TGCT risk was found in paternal exposure category where both P and L of chromium were high (vs. no chromium; OR = 1.37, 95% confidence interval; 1.05-1.79).CONCLUSIONS: Our study provides little evidence of associations between parental exposures to heavy metals/welding fumes and TGCT in offspring with the potential exception of high paternal chromium exposure.IMPACT: Further research on paternal chromium exposure is warranted. Cancer Epidemiol Biomarkers Prev; 25(10); 1426-34. ©2016 AACR.

AB - BACKGROUND: Data are scarce on the association between prenatal/preconception environmental exposure and testicular germ cell tumor (TGCT) in offspring. We examined parental occupational exposures to heavy metals and welding fumes in relation to TGCT in offspring in a registry-based case-control study (NORD-TEST Study).METHODS: We identified TGCT cases diagnosed at ages 14-49 years in Finland (1988-2012), Norway (1978-2010), and Sweden (1979-2011) through nationwide cancer registries. These cases were individually matched by country and year of birth to controls selected from population registries. Information on parental occupations was retrieved from censuses. From this, we estimated prenatal/preconception exposures of chromium, iron, nickel, lead, and welding fumes (all three countries), and cadmium (Finland only) for each parent using job-exposure matrices specifying prevalence (P) and mean exposure level (L). Exposure indices were calculated as a product of P and L (P × L), and exposure categories were based on P × L or different combinations of P and L.RESULTS: The study comprised 8,112 cases and 26,264 controls. We observed no statistically significant TGCT risk associated with presence of heavy metals/welding fumes (P × L > 0) and no dose-response relationship (Ptrend ≥ 0.32). A statistically significant elevated TGCT risk was found in paternal exposure category where both P and L of chromium were high (vs. no chromium; OR = 1.37, 95% confidence interval; 1.05-1.79).CONCLUSIONS: Our study provides little evidence of associations between parental exposures to heavy metals/welding fumes and TGCT in offspring with the potential exception of high paternal chromium exposure.IMPACT: Further research on paternal chromium exposure is warranted. Cancer Epidemiol Biomarkers Prev; 25(10); 1426-34. ©2016 AACR.

U2 - 10.1158/1055-9965.EPI-16-0328

DO - 10.1158/1055-9965.EPI-16-0328

M3 - Journal article

C2 - 27439405

VL - 25

SP - 1426

EP - 1434

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 10

ER -

ID: 176010963